Regenerative Endodontics

A Review of Current Status and a Call for Action

Peter E. Murray, Franklin Garcia-Godoy, Kenneth M. Hargreaves

Research output: Contribution to journalArticle

348 Citations (Scopus)

Abstract

Millions of teeth are saved each year by root canal therapy. Although current treatment modalities offer high levels of success for many conditions, an ideal form of therapy might consist of regenerative approaches in which diseased or necrotic pulp tissues are removed and replaced with healthy pulp tissue to revitalize teeth. Researchers are working toward this objective. Regenerative endodontics is the creation and delivery of tissues to replace diseased, missing, and traumatized pulp. This review provides an overview of regenerative endodontics and its goals, and describes possible techniques that will allow regenerative endodontics to become a reality. These potential approaches include root-canal revascularization, postnatal (adult) stem cell therapy, pulp implant, scaffold implant, three-dimensional cell printing, injectable scaffolds, and gene therapy. These regenerative endodontic techniques will possibly involve some combination of disinfection or debridement of infected root canal systems with apical enlargement to permit revascularization and use of adult stem cells, scaffolds, and growth factors. Although the challenges of introducing endodontic tissue engineering therapies are substantial, the potential benefits to patients and the profession are equally ground breaking. Patient demand is staggering both in scope and cost, because tissue engineering therapy offers the possibility of restoring natural function instead of surgical placement of an artificial prosthesis. By providing an overview of the methodological issues required to develop potential regenerative endodontic therapies, we hope to present a call for action to develop these therapies for clinical use.

Original languageEnglish (US)
Pages (from-to)377-390
Number of pages14
JournalJournal of Endodontics
Volume33
Issue number4
DOIs
StatePublished - Apr 1 2007
Externally publishedYes

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Endodontics
Cell- and Tissue-Based Therapy
Adult Stem Cells
Dental Pulp Cavity
Tissue Engineering
Tooth
Root Canal Therapy
Stem Cell Factor
Disinfection
Debridement
Therapeutics
Genetic Therapy
Prostheses and Implants
Intercellular Signaling Peptides and Proteins
Research Personnel
Costs and Cost Analysis
Injections

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Regenerative Endodontics : A Review of Current Status and a Call for Action. / Murray, Peter E.; Garcia-Godoy, Franklin; Hargreaves, Kenneth M.

In: Journal of Endodontics, Vol. 33, No. 4, 01.04.2007, p. 377-390.

Research output: Contribution to journalArticle

Murray, Peter E. ; Garcia-Godoy, Franklin ; Hargreaves, Kenneth M. / Regenerative Endodontics : A Review of Current Status and a Call for Action. In: Journal of Endodontics. 2007 ; Vol. 33, No. 4. pp. 377-390.
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