Regional brain glucose metabolism is altered during rapid eye movement sleep in the cat

A preliminary study

Ralph Lydic, Helen Baghdoyan, L. Hibbard, E. V. Bonyak, M. R. De Joseph, R. A. Hawkins

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Glucose utilization was measured in 74 brain regions of the cat during states of wakefulness or rapid eye movement (REM) sleep. These data were obtained from intact, unanesthetized animals which were instrumented for objectively measuring states of consciousness. Through a chronically implanted intravenous catheter, the cats received 250 μCi of [6−14C]glucose during REM sleep (N = 3) or during wakefulness (N = 3). After spending ≈8 min in REM sleep or in quiet wakefulness, the cats were administered a lethal dose of barbiturate and the brains were removed and processed for autoradiography. The results revealed site‐specific changes in glucose metabolism during REM sleep. Significant alterations in glucose use occurred in the thalamus, the limbic system, and specific regions of the pontine reticular formation. These data demonstrate for the first time that during states comprised entirely of REM sleep there are anatomically specific changes in cerebral glucose metabolism. The majority of brain regions exhibiting REM sleep‐dependent changes in glucose metabolism either overlapped with regions known to contain cholinergic cell bodies, or with areas that receive prominent cholinergic input.

Original languageEnglish (US)
Pages (from-to)517-529
Number of pages13
JournalJournal of Comparative Neurology
Volume304
Issue number4
DOIs
StatePublished - Jan 1 1991

Fingerprint

REM Sleep
Sleep
Cats
Glucose
Wakefulness
Brain
Cholinergic Agents
Limbic System
Autoradiography
Consciousness
Thalamus
Catheters

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Regional brain glucose metabolism is altered during rapid eye movement sleep in the cat : A preliminary study. / Lydic, Ralph; Baghdoyan, Helen; Hibbard, L.; Bonyak, E. V.; De Joseph, M. R.; Hawkins, R. A.

In: Journal of Comparative Neurology, Vol. 304, No. 4, 01.01.1991, p. 517-529.

Research output: Contribution to journalArticle

@article{e67fada475154299bdf8815368d86b67,
title = "Regional brain glucose metabolism is altered during rapid eye movement sleep in the cat: A preliminary study",
abstract = "Glucose utilization was measured in 74 brain regions of the cat during states of wakefulness or rapid eye movement (REM) sleep. These data were obtained from intact, unanesthetized animals which were instrumented for objectively measuring states of consciousness. Through a chronically implanted intravenous catheter, the cats received 250 μCi of [6−14C]glucose during REM sleep (N = 3) or during wakefulness (N = 3). After spending ≈8 min in REM sleep or in quiet wakefulness, the cats were administered a lethal dose of barbiturate and the brains were removed and processed for autoradiography. The results revealed site‐specific changes in glucose metabolism during REM sleep. Significant alterations in glucose use occurred in the thalamus, the limbic system, and specific regions of the pontine reticular formation. These data demonstrate for the first time that during states comprised entirely of REM sleep there are anatomically specific changes in cerebral glucose metabolism. The majority of brain regions exhibiting REM sleep‐dependent changes in glucose metabolism either overlapped with regions known to contain cholinergic cell bodies, or with areas that receive prominent cholinergic input.",
author = "Ralph Lydic and Helen Baghdoyan and L. Hibbard and Bonyak, {E. V.} and {De Joseph}, {M. R.} and Hawkins, {R. A.}",
year = "1991",
month = "1",
day = "1",
doi = "10.1002/cne.903040402",
language = "English (US)",
volume = "304",
pages = "517--529",
journal = "Journal of Comparative Neurology",
issn = "0021-9967",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Regional brain glucose metabolism is altered during rapid eye movement sleep in the cat

T2 - A preliminary study

AU - Lydic, Ralph

AU - Baghdoyan, Helen

AU - Hibbard, L.

AU - Bonyak, E. V.

AU - De Joseph, M. R.

AU - Hawkins, R. A.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - Glucose utilization was measured in 74 brain regions of the cat during states of wakefulness or rapid eye movement (REM) sleep. These data were obtained from intact, unanesthetized animals which were instrumented for objectively measuring states of consciousness. Through a chronically implanted intravenous catheter, the cats received 250 μCi of [6−14C]glucose during REM sleep (N = 3) or during wakefulness (N = 3). After spending ≈8 min in REM sleep or in quiet wakefulness, the cats were administered a lethal dose of barbiturate and the brains were removed and processed for autoradiography. The results revealed site‐specific changes in glucose metabolism during REM sleep. Significant alterations in glucose use occurred in the thalamus, the limbic system, and specific regions of the pontine reticular formation. These data demonstrate for the first time that during states comprised entirely of REM sleep there are anatomically specific changes in cerebral glucose metabolism. The majority of brain regions exhibiting REM sleep‐dependent changes in glucose metabolism either overlapped with regions known to contain cholinergic cell bodies, or with areas that receive prominent cholinergic input.

AB - Glucose utilization was measured in 74 brain regions of the cat during states of wakefulness or rapid eye movement (REM) sleep. These data were obtained from intact, unanesthetized animals which were instrumented for objectively measuring states of consciousness. Through a chronically implanted intravenous catheter, the cats received 250 μCi of [6−14C]glucose during REM sleep (N = 3) or during wakefulness (N = 3). After spending ≈8 min in REM sleep or in quiet wakefulness, the cats were administered a lethal dose of barbiturate and the brains were removed and processed for autoradiography. The results revealed site‐specific changes in glucose metabolism during REM sleep. Significant alterations in glucose use occurred in the thalamus, the limbic system, and specific regions of the pontine reticular formation. These data demonstrate for the first time that during states comprised entirely of REM sleep there are anatomically specific changes in cerebral glucose metabolism. The majority of brain regions exhibiting REM sleep‐dependent changes in glucose metabolism either overlapped with regions known to contain cholinergic cell bodies, or with areas that receive prominent cholinergic input.

UR - http://www.scopus.com/inward/record.url?scp=0026099234&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026099234&partnerID=8YFLogxK

U2 - 10.1002/cne.903040402

DO - 10.1002/cne.903040402

M3 - Article

VL - 304

SP - 517

EP - 529

JO - Journal of Comparative Neurology

JF - Journal of Comparative Neurology

SN - 0021-9967

IS - 4

ER -