Regionalized adaptations and muscle fiber proliferation in stretch-induced enlargement

Stephen Alway, P. K. Winchester, M. E. Davis, W. J. Gonyea

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

The relative contribution of increases in fiber area to stretch-induced muscle enlargement was evaluated in the slow tonic fibers of the anterior latissimus dorsi of adult Japanese quails. A weight corresponding to 10% of the bird's body mass was attached to one wing. Thirty days of stretch in 34 birds averaged 171.8 ± 13.5% increase in muscle mass and 23.5 ± 0.8% increase in muscle fiber length. The volume density of noncontractile tissue increased in middle and distal regions of stretch-enlarged muscles. Mean fiber cross-sectional area increased 56.7 ± 12.3% in the midregion of stretched muscles. Further analysis indicated slow β-fiber hypertrophy occurred in proximal, middle, and distal regions; however, fast α-type fiber hypertrophy was limited to middle regions of stretched muscles. Stretched muscles had a significant increase in the frequency of slow β-fibers that were < 500 μm2 in all regions and fast α-type fibers in middle and distal regions. Total fiber number was determined after nitric acid digestion of connective tissue in 10 birds. Fiber number increased 51.8 ± 19.4% in stretched muscle. These results are the first to clearly show that muscle fiber proliferation contributes substantially to adult skeletal muscle stretch-induced enlargement, although we do not know whether the responses of the slow tonic anterior latissimus dorsi might be similar or different from mammalian twitch muscle.

Original languageEnglish (US)
Pages (from-to)771-781
Number of pages11
JournalJournal of Applied Physiology
Volume66
Issue number2
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Muscles
Birds
Superficial Back Muscles
Hypertrophy
Nitric Acid
Coturnix
Connective Tissue
Digestion
Skeletal Muscle
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Regionalized adaptations and muscle fiber proliferation in stretch-induced enlargement. / Alway, Stephen; Winchester, P. K.; Davis, M. E.; Gonyea, W. J.

In: Journal of Applied Physiology, Vol. 66, No. 2, 01.01.1989, p. 771-781.

Research output: Contribution to journalArticle

Alway, Stephen ; Winchester, P. K. ; Davis, M. E. ; Gonyea, W. J. / Regionalized adaptations and muscle fiber proliferation in stretch-induced enlargement. In: Journal of Applied Physiology. 1989 ; Vol. 66, No. 2. pp. 771-781.
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