Regular nonsteroidal anti-inflammatory drug use and erectile dysfunction

Joseph Gleason, Jeffrey M. Slezak, Howard Jung, Kristi Reynolds, Stephen K. Van Den Eeden, Reina Haque, Virginia P. Quinn, Ronald K. Loo, Steven J. Jacobsen

Research output: Contribution to journalArticle

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Abstract

Purpose: Previous data suggest a potential relationship between inflammation and erectile dysfunction. If it is causal, nonsteroidal anti-inflammatory drug use should be inversely associated with erectile dysfunction. To this end we examined the association between nonsteroidal anti-inflammatory drug use and erectile dysfunction in a large, ethnically diverse cohort of men enrolled in the California Men's Health Study. Materials and Methods: This prospective cohort study enrolled male members of the Kaiser Permanente managed care plans who were 45 to 69 years old beginning in 2002. Erectile dysfunction was assessed by questionnaire. Nonsteroidal anti-inflammatory drug exposure was determined by automated pharmacy data and self-reported use. Results: Of the 80,966 men in this study 47.4% were considered nonsteroidal anti-inflammatory drug users based on the definitions used and 29.3% reported moderate or severe erectile dysfunction. Nonsteroidal anti-inflammatory drug use and erectile dysfunction strongly correlated with age with regular drug use increasing from 34.5% in men at ages 45 to 49 years to 54.7% in men 60 to 69 years old with erectile dysfunction increasing from 13% to 42%. The unadjusted OR for the association of nonsteroidal anti-inflammatory drugs and erectile dysfunction was 2.40 (95% CI 2.27, 2.53). With adjustment for age, race/ethnicity, smoking status, diabetes mellitus, hypertension, hyperlipidemia, peripheral vascular disease, coronary artery disease and body mass index, a positive association persisted (adjusted OR 1.38). The association persisted when using a stricter definition of nonsteroidal anti-inflammatory drug exposure. Conclusions: These data suggest that regular nonsteroidal anti-inflammatory drug use is associated with erectile dysfunction beyond what would be expected due to age and comorbidity.

Original languageEnglish (US)
Pages (from-to)1388-1393
Number of pages6
JournalJournal of Urology
Volume185
Issue number4
DOIs
StatePublished - Apr 1 2011
Externally publishedYes

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Erectile Dysfunction
Anti-Inflammatory Agents
Pharmaceutical Preparations
Men's Health
Peripheral Vascular Diseases
Managed Care Programs
Drug Users
Hyperlipidemias
Comorbidity
Coronary Artery Disease
Diabetes Mellitus
Body Mass Index
Cohort Studies
Smoking
Prospective Studies
Hypertension
Inflammation

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Gleason, J., Slezak, J. M., Jung, H., Reynolds, K., Van Den Eeden, S. K., Haque, R., ... Jacobsen, S. J. (2011). Regular nonsteroidal anti-inflammatory drug use and erectile dysfunction. Journal of Urology, 185(4), 1388-1393. https://doi.org/10.1016/j.juro.2010.11.092

Regular nonsteroidal anti-inflammatory drug use and erectile dysfunction. / Gleason, Joseph; Slezak, Jeffrey M.; Jung, Howard; Reynolds, Kristi; Van Den Eeden, Stephen K.; Haque, Reina; Quinn, Virginia P.; Loo, Ronald K.; Jacobsen, Steven J.

In: Journal of Urology, Vol. 185, No. 4, 01.04.2011, p. 1388-1393.

Research output: Contribution to journalArticle

Gleason, J, Slezak, JM, Jung, H, Reynolds, K, Van Den Eeden, SK, Haque, R, Quinn, VP, Loo, RK & Jacobsen, SJ 2011, 'Regular nonsteroidal anti-inflammatory drug use and erectile dysfunction', Journal of Urology, vol. 185, no. 4, pp. 1388-1393. https://doi.org/10.1016/j.juro.2010.11.092
Gleason J, Slezak JM, Jung H, Reynolds K, Van Den Eeden SK, Haque R et al. Regular nonsteroidal anti-inflammatory drug use and erectile dysfunction. Journal of Urology. 2011 Apr 1;185(4):1388-1393. https://doi.org/10.1016/j.juro.2010.11.092
Gleason, Joseph ; Slezak, Jeffrey M. ; Jung, Howard ; Reynolds, Kristi ; Van Den Eeden, Stephen K. ; Haque, Reina ; Quinn, Virginia P. ; Loo, Ronald K. ; Jacobsen, Steven J. / Regular nonsteroidal anti-inflammatory drug use and erectile dysfunction. In: Journal of Urology. 2011 ; Vol. 185, No. 4. pp. 1388-1393.
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abstract = "Purpose: Previous data suggest a potential relationship between inflammation and erectile dysfunction. If it is causal, nonsteroidal anti-inflammatory drug use should be inversely associated with erectile dysfunction. To this end we examined the association between nonsteroidal anti-inflammatory drug use and erectile dysfunction in a large, ethnically diverse cohort of men enrolled in the California Men's Health Study. Materials and Methods: This prospective cohort study enrolled male members of the Kaiser Permanente managed care plans who were 45 to 69 years old beginning in 2002. Erectile dysfunction was assessed by questionnaire. Nonsteroidal anti-inflammatory drug exposure was determined by automated pharmacy data and self-reported use. Results: Of the 80,966 men in this study 47.4{\%} were considered nonsteroidal anti-inflammatory drug users based on the definitions used and 29.3{\%} reported moderate or severe erectile dysfunction. Nonsteroidal anti-inflammatory drug use and erectile dysfunction strongly correlated with age with regular drug use increasing from 34.5{\%} in men at ages 45 to 49 years to 54.7{\%} in men 60 to 69 years old with erectile dysfunction increasing from 13{\%} to 42{\%}. The unadjusted OR for the association of nonsteroidal anti-inflammatory drugs and erectile dysfunction was 2.40 (95{\%} CI 2.27, 2.53). With adjustment for age, race/ethnicity, smoking status, diabetes mellitus, hypertension, hyperlipidemia, peripheral vascular disease, coronary artery disease and body mass index, a positive association persisted (adjusted OR 1.38). The association persisted when using a stricter definition of nonsteroidal anti-inflammatory drug exposure. Conclusions: These data suggest that regular nonsteroidal anti-inflammatory drug use is associated with erectile dysfunction beyond what would be expected due to age and comorbidity.",
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AU - Loo, Ronald K.

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AB - Purpose: Previous data suggest a potential relationship between inflammation and erectile dysfunction. If it is causal, nonsteroidal anti-inflammatory drug use should be inversely associated with erectile dysfunction. To this end we examined the association between nonsteroidal anti-inflammatory drug use and erectile dysfunction in a large, ethnically diverse cohort of men enrolled in the California Men's Health Study. Materials and Methods: This prospective cohort study enrolled male members of the Kaiser Permanente managed care plans who were 45 to 69 years old beginning in 2002. Erectile dysfunction was assessed by questionnaire. Nonsteroidal anti-inflammatory drug exposure was determined by automated pharmacy data and self-reported use. Results: Of the 80,966 men in this study 47.4% were considered nonsteroidal anti-inflammatory drug users based on the definitions used and 29.3% reported moderate or severe erectile dysfunction. Nonsteroidal anti-inflammatory drug use and erectile dysfunction strongly correlated with age with regular drug use increasing from 34.5% in men at ages 45 to 49 years to 54.7% in men 60 to 69 years old with erectile dysfunction increasing from 13% to 42%. The unadjusted OR for the association of nonsteroidal anti-inflammatory drugs and erectile dysfunction was 2.40 (95% CI 2.27, 2.53). With adjustment for age, race/ethnicity, smoking status, diabetes mellitus, hypertension, hyperlipidemia, peripheral vascular disease, coronary artery disease and body mass index, a positive association persisted (adjusted OR 1.38). The association persisted when using a stricter definition of nonsteroidal anti-inflammatory drug exposure. Conclusions: These data suggest that regular nonsteroidal anti-inflammatory drug use is associated with erectile dysfunction beyond what would be expected due to age and comorbidity.

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