Regulation by oestrogen of carnitine palmitoyltransferase in hepatic mitochondria

I. Weinstein, George Cook, M. Heimberg

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Treatment of female rats with ethynyloestradiol decreased both the activity of carnitine palmitoyltransferase and its K(i) value for malonyl-CoA compared with pair-fed control rats. In starved rats, carnitine palmitoyltransferase activity and its K(i) value for malonyl-CoA were both elevated as expected. Oestrogen treatment had no effect on carnitine palmitoyltransferase activity in the starved state, but the K(i) value for malonyl-CoA was substantially decreased by oestrogen. Treatment with a more physiological concentration of ethynyloestradiol (15 μg/kg body wt. per day) also produced a decrease in the K(i) value for malonyl-CoA. These data suggest that the oestrogen may produce its anti-ketogenic effect by increasing the affinity of carnitine palmitoyltransferase for its physiological inhibitor, malonyl-CoA.

Original languageEnglish (US)
Pages (from-to)593-596
Number of pages4
JournalBiochemical Journal
Volume237
Issue number2
DOIs
StatePublished - Jan 1 1986

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Malonyl Coenzyme A
Carnitine O-Palmitoyltransferase
Mitochondria
Estrogens
Liver
Rats
Rat control

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Regulation by oestrogen of carnitine palmitoyltransferase in hepatic mitochondria. / Weinstein, I.; Cook, George; Heimberg, M.

In: Biochemical Journal, Vol. 237, No. 2, 01.01.1986, p. 593-596.

Research output: Contribution to journalArticle

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