DAS ENDOTHEL ALS ZENTRALE SCHALTSTELLE DER GERINNUNGSKASKADE

Translated title of the contribution: Regulation of coagulation by endothelial cells

P. P. Nawroth, David Stern

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Regulation of coagulation by endothelial cells has been the focus of intense studies during recent years. The importance of cellular receptors for coagulation factors leads to a model of the prethrombotic state and perhaps to the possibility of receptor blockade as an anticoagulant therapy. The prethrombotic state is initiated by stimuli such as Interleukin 1, Tumor Necrosis Factor, endotoxin, or norepinephrin. These agents shift the steady state of coagulant reactions on the surface of normal anticoagulant active endothelial cells to a prethrombotic surface, capable of initiating coagulation and promoting clot formation. These stimulated endothelial cells have an increased expression of procoagulant and a decreased expression of anticoagulant binding sites for clotting factors.

Original languageGerman
Pages (from-to)16-24
Number of pages9
JournalZeitschrift fur Kardiologie
Volume78
Issue numberSUPPL. 6
StatePublished - 1989
Externally publishedYes

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Anticoagulants
Blood Coagulation Factors
Endothelial Cells
Coagulants
Interleukin-1
Endotoxins
Tumor Necrosis Factor-alpha
Binding Sites
Therapeutics

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

DAS ENDOTHEL ALS ZENTRALE SCHALTSTELLE DER GERINNUNGSKASKADE. / Nawroth, P. P.; Stern, David.

In: Zeitschrift fur Kardiologie, Vol. 78, No. SUPPL. 6, 1989, p. 16-24.

Research output: Contribution to journalArticle

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