Regulation of contractile protein gene expression in unloaded mouse skeletal muscle.

D. S. Criswell, James Carson, F. W. Booth

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Hindlimb unloading was performed on mice in an effort to study the regulation of contractile protein genes. In particular, the regulation of myosin heavy chain IIb was examined. During unloading, muscle fibers undergo a type conversion. Preliminary data from this study does not support the hypothesis that the fiber type conversion is due to an increase in promoter activity of fast isoform genes, such as myosin heavy chain IIb. The consequences of this finding are examined, with particular focus on other factors controlling gene regulation.

Original languageEnglish (US)
Pages (from-to)58-60
Number of pages3
JournalJournal of gravitational physiology : a journal of the International Society for Gravitational Physiology
Volume3
Issue number2
StatePublished - Jan 1 1996
Externally publishedYes

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Contractile Proteins
Skeletal Muscle
Myosin Heavy Chains
Gene Expression
Genes
Hindlimb Suspension
Protein Isoforms
Muscles

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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