Regulation of expression, activity and localization of fungal chitin synthases

Luise E. Rogg, Jarrod Fortwendel, Praveen R. Juvvadi, William J. Steinbach

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

The fungal cell wall represents an attractive target for pharmacologic inhibition, as many of the components are fungal-specific. Though targeted inhibition of β-glucan synthesis is effective treatment for certain fungal infections, the ability of the cell wall to dynamically compensate via the cell wall integrity pathway may limit overall efficacy. To date, chitin synthesis inhibitors have not been successfully deployed in the clinical setting. Fungal chitin synthesis is a complex and highly regulated process. Regulation of chitin synthesis occurs on multiple levels, thus targeting of these regulatory pathways may represent an exciting alternative approach. A variety of signaling pathways have been implicated in chitin synthase regulation, at both transcriptional and post-transcriptional levels. Recent research suggests that localization of chitin synthases likely represents a major regulatory mechanism. However, much of the regulatory machinery is not necessarily shared among different chitin synthases. Thus, an in-depth understanding of the precise roles of each protein in cell wall maintenance and repair will be essential to identifying the most likely therapeutic targets.

Original languageEnglish (US)
Pages (from-to)2-17
Number of pages16
JournalMedical Mycology
Volume50
Issue number1
DOIs
StatePublished - Jan 1 2012

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Chitin Synthase
Cell Wall
Chitin
Fungal Structures
Glucans
Mycoses
Maintenance
Research
Proteins

All Science Journal Classification (ASJC) codes

  • Infectious Diseases

Cite this

Regulation of expression, activity and localization of fungal chitin synthases. / Rogg, Luise E.; Fortwendel, Jarrod; Juvvadi, Praveen R.; Steinbach, William J.

In: Medical Mycology, Vol. 50, No. 1, 01.01.2012, p. 2-17.

Research output: Contribution to journalReview article

Rogg, Luise E. ; Fortwendel, Jarrod ; Juvvadi, Praveen R. ; Steinbach, William J. / Regulation of expression, activity and localization of fungal chitin synthases. In: Medical Mycology. 2012 ; Vol. 50, No. 1. pp. 2-17.
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