Regulation of IL-18 expression by CRH in mouse microglial cells

Yoolhee Yang, Eunsil Hahm, Young In Kim Hoehamer, Jaeseung Kang, Wangjae Lee, Innoc Han, Pyungkeun Myung, Hyungsik Kang, Hyunjeong Park, Daeho Cho

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Corticotropin releasing hormone (CRH) is a major regulator of the stress response. This study examined whether CRH regulates interleukin-18 expression on microglia, BV2. Our data show that CRH enhanced IL-18 expression and significantly induced the secretion of functional IL-18 protein. Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-l-cystein (NAC), which suggests that reactive oxygen intermediates (ROI) may be involved in regulating IL-18. Indeed, it was also found that CRH increased the generation of ROI. Taken together, these results indicate that CRH is an important mediator that regulates IL-18 expression in the brain during stress.

Original languageEnglish (US)
Pages (from-to)291-296
Number of pages6
JournalImmunology Letters
Volume98
Issue number2
DOIs
StatePublished - May 15 2005

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Interleukin-18
Corticotropin-Releasing Hormone
Oxygen
Microglia
Brain
Proteins

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Yang, Y., Hahm, E., Kim Hoehamer, Y. I., Kang, J., Lee, W., Han, I., ... Cho, D. (2005). Regulation of IL-18 expression by CRH in mouse microglial cells. Immunology Letters, 98(2), 291-296. https://doi.org/10.1016/j.imlet.2004.12.003

Regulation of IL-18 expression by CRH in mouse microglial cells. / Yang, Yoolhee; Hahm, Eunsil; Kim Hoehamer, Young In; Kang, Jaeseung; Lee, Wangjae; Han, Innoc; Myung, Pyungkeun; Kang, Hyungsik; Park, Hyunjeong; Cho, Daeho.

In: Immunology Letters, Vol. 98, No. 2, 15.05.2005, p. 291-296.

Research output: Contribution to journalArticle

Yang, Y, Hahm, E, Kim Hoehamer, YI, Kang, J, Lee, W, Han, I, Myung, P, Kang, H, Park, H & Cho, D 2005, 'Regulation of IL-18 expression by CRH in mouse microglial cells', Immunology Letters, vol. 98, no. 2, pp. 291-296. https://doi.org/10.1016/j.imlet.2004.12.003
Yang Y, Hahm E, Kim Hoehamer YI, Kang J, Lee W, Han I et al. Regulation of IL-18 expression by CRH in mouse microglial cells. Immunology Letters. 2005 May 15;98(2):291-296. https://doi.org/10.1016/j.imlet.2004.12.003
Yang, Yoolhee ; Hahm, Eunsil ; Kim Hoehamer, Young In ; Kang, Jaeseung ; Lee, Wangjae ; Han, Innoc ; Myung, Pyungkeun ; Kang, Hyungsik ; Park, Hyunjeong ; Cho, Daeho. / Regulation of IL-18 expression by CRH in mouse microglial cells. In: Immunology Letters. 2005 ; Vol. 98, No. 2. pp. 291-296.
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