Regulation of the coagulation system by vascular endothelial cells

David Stern, Evan Kaiser, Peter P. Nawroth

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The endothelium plays an active role in the regulation of the coagulation mechanism. Multiple anticoagulant properties are operative on the cell surface in homeostasis. In the protein C/protein S pathway, for example, endothelium provides cofactors promoting activation of protein C, assembly of the activated protein C/protein S complex, and synthesizes protein S. In contrast, following exposure to cytokines and other pathologic stimuli, endothelial cell activation occurs. This activated state includes upregulation of procoagulant properties, such as tissue factor, with concomitant downregulation of anticoagulant cofactors, such as thrombomodulin. Modulation of endothelial cell coagulant properties by cytokines provides a mechanism linking activation of the clotting mechanism to the cellular response to environmental stimuli.

Original languageEnglish (US)
Pages (from-to)202-214
Number of pages13
JournalPathophysiology of Haemostasis and Thrombosis
Volume18
Issue number4-6
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

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Protein S
Protein C
Endothelial Cells
Anticoagulants
Endothelium
Cytokines
Thrombomodulin
Coagulants
Thromboplastin
Homeostasis
Up-Regulation
Down-Regulation

All Science Journal Classification (ASJC) codes

  • Hematology
  • Physiology (medical)

Cite this

Regulation of the coagulation system by vascular endothelial cells. / Stern, David; Kaiser, Evan; Nawroth, Peter P.

In: Pathophysiology of Haemostasis and Thrombosis, Vol. 18, No. 4-6, 01.01.1988, p. 202-214.

Research output: Contribution to journalArticle

Stern, David ; Kaiser, Evan ; Nawroth, Peter P. / Regulation of the coagulation system by vascular endothelial cells. In: Pathophysiology of Haemostasis and Thrombosis. 1988 ; Vol. 18, No. 4-6. pp. 202-214.
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