Regulation of the RAG-1 promoter by the NF-Y transcription factor

Stephen T. Brown, Gustavo Miranda-Carboni, Zoran Galic, Isamu Z. Hartman, Christopher J. Lyon, Renato J. Aguilera

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

We have cloned the RAG-1 promoter region and have determined that almost all detectable promoter activity resides within a 208-bp fragment. Sequence analysis of this promoter region has identified potential recognition motifs for a number of lymphocyte-restricted and ubiquitous transcription factors. Subsequent assays have revealed that the NF-Y transcription factor interacts with a CCAAT site within the RAG-1 promoter and appears to play an important role in the posi-tive transcriptional regulation of this gene.

Original languageEnglish (US)
Pages (from-to)5071-5074
Number of pages4
JournalJournal of Immunology
Volume158
Issue number11
StatePublished - Dec 1 1997
Externally publishedYes

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Genetic Promoter Regions
Transcription Factors
Lymphocyte Count
Sequence Analysis
Genes

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Brown, S. T., Miranda-Carboni, G., Galic, Z., Hartman, I. Z., Lyon, C. J., & Aguilera, R. J. (1997). Regulation of the RAG-1 promoter by the NF-Y transcription factor. Journal of Immunology, 158(11), 5071-5074.

Regulation of the RAG-1 promoter by the NF-Y transcription factor. / Brown, Stephen T.; Miranda-Carboni, Gustavo; Galic, Zoran; Hartman, Isamu Z.; Lyon, Christopher J.; Aguilera, Renato J.

In: Journal of Immunology, Vol. 158, No. 11, 01.12.1997, p. 5071-5074.

Research output: Contribution to journalArticle

Brown, ST, Miranda-Carboni, G, Galic, Z, Hartman, IZ, Lyon, CJ & Aguilera, RJ 1997, 'Regulation of the RAG-1 promoter by the NF-Y transcription factor', Journal of Immunology, vol. 158, no. 11, pp. 5071-5074.
Brown ST, Miranda-Carboni G, Galic Z, Hartman IZ, Lyon CJ, Aguilera RJ. Regulation of the RAG-1 promoter by the NF-Y transcription factor. Journal of Immunology. 1997 Dec 1;158(11):5071-5074.
Brown, Stephen T. ; Miranda-Carboni, Gustavo ; Galic, Zoran ; Hartman, Isamu Z. ; Lyon, Christopher J. ; Aguilera, Renato J. / Regulation of the RAG-1 promoter by the NF-Y transcription factor. In: Journal of Immunology. 1997 ; Vol. 158, No. 11. pp. 5071-5074.
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