Regulatory immunotherapy in bone marrow transplantation

Vanessa Morales-Tirado, Wioleta Luszczek, Marié Van Der Merwe, Asha Pillai

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Every year individuals receive hematopoietic stem cell transplantation (HSCT) to eradicate malignant and nonmalignant disease. The immunobiology of allotransplantation is an area of ongoing discovery, from the recipient's conditioning treatment prior to the transplant to the donor cell populations responsible for engraftment, graft-versus-host disease, and graft-versus-tumor effect. In this review, we focus on donor-type immunoregulatory T cells, namely, natural killer T cells (NKT) and regulatory T cells (Treg), and their current and potential roles in tolerance induction after allogeneic HSCT.

Original languageEnglish (US)
Pages (from-to)2620-2634
Number of pages15
JournalTheScientificWorldJournal
Volume11
DOIs
StatePublished - Dec 1 2011

Fingerprint

T-cells
transplantation
Hematopoietic Stem Cell Transplantation
Bone Marrow Transplantation
Immunotherapy
bone
Bone
Stem cells
Transplants
Grafts
Natural Killer T-Cells
Graft vs Host Disease
Regulatory T-Lymphocytes
tumor
conditioning
tolerance
T-Lymphocytes
Tumors
Cells
Population

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

Cite this

Regulatory immunotherapy in bone marrow transplantation. / Morales-Tirado, Vanessa; Luszczek, Wioleta; Van Der Merwe, Marié; Pillai, Asha.

In: TheScientificWorldJournal, Vol. 11, 01.12.2011, p. 2620-2634.

Research output: Contribution to journalReview article

Morales-Tirado, Vanessa ; Luszczek, Wioleta ; Van Der Merwe, Marié ; Pillai, Asha. / Regulatory immunotherapy in bone marrow transplantation. In: TheScientificWorldJournal. 2011 ; Vol. 11. pp. 2620-2634.
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