Relapsing polychondritis

Ken Hashimoto, Charles R. Arkin, Andrew Kang

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Ear cartilage from a typical case of relapsing polychondritis was examined with the electron microscope. A large number of dense granules and vesicles, which were compatible with matrix vesicles or lysosomes, surrounded the affected chondrocytes. In less severely damaged chondrocytes, these granules and vesicles appeared to be formed by pinching off of the cytoplasmic processes or by budding from the processes. Calcification of the granules was minimal. In severely damaged chondrocytes, an admixture of these granules and cytoplasmic organelles occurred. It is speculated that many of these dense granules are lysosomal in nature and that they may produce inflammation and reduce the proteoglycan content of cartilage.

Original languageEnglish (US)
Pages (from-to)91-99
Number of pages9
JournalArthritis & Rheumatism
Volume20
Issue number1
DOIs
StatePublished - Jan 1 1977

Fingerprint

Relapsing Polychondritis
Chondrocytes
Ear Cartilage
Cytoplasmic Granules
Proteoglycans
Lysosomes
Organelles
Cartilage
Electrons
Inflammation

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

Relapsing polychondritis. / Hashimoto, Ken; Arkin, Charles R.; Kang, Andrew.

In: Arthritis & Rheumatism, Vol. 20, No. 1, 01.01.1977, p. 91-99.

Research output: Contribution to journalArticle

Hashimoto, K, Arkin, CR & Kang, A 1977, 'Relapsing polychondritis', Arthritis & Rheumatism, vol. 20, no. 1, pp. 91-99. https://doi.org/10.1002/art.1780200116
Hashimoto, Ken ; Arkin, Charles R. ; Kang, Andrew. / Relapsing polychondritis. In: Arthritis & Rheumatism. 1977 ; Vol. 20, No. 1. pp. 91-99.
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