Relation between mixed venous oxygen saturation and cardiac index; Nonlinearity and normalization for oxygen uptake and hemoglobin

A. Jain, S. G. Shroff, J. S. Janicki, H. K. Reddy, Karl Weber

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The ability of mixed venous oxygen saturation (SvO2) monitoring to reflect changes in cardiac index (CI) with therapy in critically ill patients is unclear. To this end, SvO2 and CI were measured before and during an infusion of enoximone and/or dobutamine in 30 patients with advanced heart failure. A nonlinear relationship was observed between SvO2 and CI with the nonlinear correlation coefficient being 0.52. On normalizing for individual differences in hemoglobin and oxygen consumption, this correlation coefficient became 0.90. Further analysis of individual data was performed using linear regression, and the slopes and correlation coefficients were found to span a wide range (slope: -10.0 to 30.9 min-m2/L, r: -0.27 to 0.99). However, the mean slope and correlation coefficient for patients with baseline CI and SvO2 <21/min/m2 and <55 percent were 18.3 min-m2/L and 0.87, respectively, while those for the remainder of patients were only 3.1 min-m2/L and 0.42, respectively. Thus, the nonlinear correlation coefficient of the SvO2-CI relationship in a group of patients is dependent on the homogeneity of their oxygen consumption and hemoglobin concentration. Furthermore, the ability of SvO2 to serve as a therapeutic indicator in any given patient is dependent on baseline SvO2 and CI.

Original languageEnglish (US)
Pages (from-to)1403-1409
Number of pages7
JournalChest
Volume99
Issue number6
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

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Hemoglobins
Oxygen
Aptitude
Oxygen Consumption
Enoximone
Dobutamine
Critical Illness
Individuality
Linear Models
Heart Failure
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Relation between mixed venous oxygen saturation and cardiac index; Nonlinearity and normalization for oxygen uptake and hemoglobin. / Jain, A.; Shroff, S. G.; Janicki, J. S.; Reddy, H. K.; Weber, Karl.

In: Chest, Vol. 99, No. 6, 01.01.1991, p. 1403-1409.

Research output: Contribution to journalArticle

Jain, A. ; Shroff, S. G. ; Janicki, J. S. ; Reddy, H. K. ; Weber, Karl. / Relation between mixed venous oxygen saturation and cardiac index; Nonlinearity and normalization for oxygen uptake and hemoglobin. In: Chest. 1991 ; Vol. 99, No. 6. pp. 1403-1409.
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