Relation of β-casomorphin to apnea in sudden infant death syndrome

Zhongjie Sun, Zhonge Zhang, Xiuqing Wang, Robert Cade, Zaher Elmir, Melvin Fregly

Research output: Contribution to journalReview article

54 Citations (Scopus)

Abstract

Sudden infant death syndrome (SIDS) is the most common cause of death in infants and its pathogenesis is complex and multifactorial. The aim of this review is to summarize recent novel findings regarding the possible association of β-casomorphin (β-CM) to apnea in SIDS, which has not been widely appreciated by pediatricians and scientists. β-CM is an exogenous bioactive peptide derived from casein, a major protein in milk and milk products, which has opioid activity. Mechanistically, circulation of this peptide into the infant's immature central nervous system might inhibit the respiratory center in the brainstem leading to apnea and death. This paper will review the possible relationship between β-CM and SIDS in the context of passage of β-CM through the gastrointestinal tract and the blood-brain barrier (BBB), permeability of the BBB to peptides in infants, and characterization of the casomorphin system in the brain.

Original languageEnglish (US)
Pages (from-to)937-943
Number of pages7
JournalPeptides
Volume24
Issue number6
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

Fingerprint

Sudden Infant Death
Apnea
Blood-Brain Barrier
Peptides
Respiratory Center
Milk Proteins
Neurology
Caseins
Opioid Analgesics
Brain Stem
Gastrointestinal Tract
Cause of Death
Permeability
Brain
Milk
Central Nervous System
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

Cite this

Sun, Z., Zhang, Z., Wang, X., Cade, R., Elmir, Z., & Fregly, M. (2003). Relation of β-casomorphin to apnea in sudden infant death syndrome. Peptides, 24(6), 937-943. https://doi.org/10.1016/S0196-9781(03)00156-6

Relation of β-casomorphin to apnea in sudden infant death syndrome. / Sun, Zhongjie; Zhang, Zhonge; Wang, Xiuqing; Cade, Robert; Elmir, Zaher; Fregly, Melvin.

In: Peptides, Vol. 24, No. 6, 01.06.2003, p. 937-943.

Research output: Contribution to journalReview article

Sun, Z, Zhang, Z, Wang, X, Cade, R, Elmir, Z & Fregly, M 2003, 'Relation of β-casomorphin to apnea in sudden infant death syndrome', Peptides, vol. 24, no. 6, pp. 937-943. https://doi.org/10.1016/S0196-9781(03)00156-6
Sun, Zhongjie ; Zhang, Zhonge ; Wang, Xiuqing ; Cade, Robert ; Elmir, Zaher ; Fregly, Melvin. / Relation of β-casomorphin to apnea in sudden infant death syndrome. In: Peptides. 2003 ; Vol. 24, No. 6. pp. 937-943.
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