Relationship of hippocampal sclerosis to duration and age of onset of epilepsy, and childhood febrile seizures in temporal lobectomy patients

Keith G. Davies, Bruce P. Hermann, F Dohan, Kevin Foley, Andrew J. Bush, Allen R. Wyler

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Abstract

Controversy exists as to whether hippocampal sclerosis (HS) is a preexisting cause or a consequence of seizures. We investigated 122 consecutive patients who underwent anterior temporal lobectomy for intractable epilepsy between 1989 and 1992. MRI scans were normal apart from evidence of HS in 5 cases. The degree of HS was graded from 0 to 4. There was a significant inverse correlation between age of seizure onset and grade of HS (P < 0.0001), and a positive correlation between duration of epilepsy and grade of HS (P < 0.001). Using a dichotomous grouping of HS (HPSC - for grades 0 and 1 [no/mild HS], and HPSC + for grades 3 and 4 [moderate/marked HS]), there was a positive correlation between HPSC + and a history of childhood febrile seizures (CFS) (P = 0.003), earlier age of onset of epilepsy (P < 0.001) and longer duration of epilepsy (P < 0.001). There was no correlation with history of particularly prolonged individual seizures. Partial correlations after controlling for age at onset of epilepsy showed that there was no kroger a significant relationship between HPSC + and duration of epilepsy. After controlling for duration of epilepsy, the relationship between HPSC + and age of onset remained significant (P < 0.001). The correlation between HPSC + and CFS, controlling for age at onset, was not significant. A series of logistic regression analyses showed age at onset to be the only predictor of HPSC +. It is concluded that this is supportive evidence for preexisting HS being a cause of temporal lobe epilepsy and not a consequence of seizures.

Original languageEnglish (US)
Pages (from-to)119-126
Number of pages8
JournalEpilepsy Research
Volume24
Issue number2
DOIs
StatePublished - Jan 1 1996

Fingerprint

Febrile Seizures
Sclerosis
Age of Onset
Epilepsy
Seizures
Anterior Temporal Lobectomy
Temporal Lobe Epilepsy
Logistic Models
Regression Analysis
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Relationship of hippocampal sclerosis to duration and age of onset of epilepsy, and childhood febrile seizures in temporal lobectomy patients. / Davies, Keith G.; Hermann, Bruce P.; Dohan, F; Foley, Kevin; Bush, Andrew J.; Wyler, Allen R.

In: Epilepsy Research, Vol. 24, No. 2, 01.01.1996, p. 119-126.

Research output: Contribution to journalArticle

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