Relationships among cytokines (IL-1, TNF, and IL-8) and histologic markers of acute ascending intrauterine infection

Nicholas Potter, Linda Kosuda, Pierluigi E. Bigazzi, Alfred D. Fleming, Anthony M. Vintzileos, Carol Homon, Carolyn M. Salafia

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Amniotic fluid levels of interleukin-1β (IL-1β tumor necrosis factor-α (TNF-α and interleukin-8 (IL-8) were determined in 13 pregnancies presenting with preterm spontaneous membrane rupture in which there were no clinical indications of intraamniotic infection. These levels were compared to the placental histology. All 8 cases in which elevated cytokine levels were identified also had histologic evidence of both maternal and fetal acute inflammation in choriodecidua and chorionic plate, and umbilical and chorionic vessels, respectively. Cytokine concentrations correlated with the severity of maternal inflammation, but not the severity of fetal inflammation as assessed histologically. Elevated levels of both IL-1β and TNF-α were not uniformly observed in amniotic fluid; all cases with either elevated IL-1β of TNF-α had elevated levels of IL-8. Microbial studies of the 8 patients with histologic acute inflammation showed 5 with positive amniotic fluid cultures and/or gram stains. One had positive gram stain only for gram positive cocci, and the 4 remaining grew mixed vaginal flora (2), Fusobacterium spp. (1), and E. coli (1). One aspect of the functional immaturity of the fetal polymorphonuclear leukocyte may be related to impaired response to IL-8. In addition, the presence of IL-8 may be a clinical indicator of intraamniotic infection.

Original languageEnglish (US)
Pages (from-to)142-147
Number of pages6
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume1
Issue number3
DOIs
StatePublished - Jan 1 1992

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Interleukin-8
Interleukin-1
Amniotic Fluid
Cytokines
Inflammation
Infection
Mothers
Fusobacterium
Umbilicus
Gram-Positive Cocci
Spontaneous Rupture
Histology
Neutrophils
Tumor Necrosis Factor-alpha
Escherichia coli
Pregnancy
Membranes
Gram's stain

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Relationships among cytokines (IL-1, TNF, and IL-8) and histologic markers of acute ascending intrauterine infection. / Potter, Nicholas; Kosuda, Linda; Bigazzi, Pierluigi E.; Fleming, Alfred D.; Vintzileos, Anthony M.; Homon, Carol; Salafia, Carolyn M.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 1, No. 3, 01.01.1992, p. 142-147.

Research output: Contribution to journalArticle

Potter, Nicholas ; Kosuda, Linda ; Bigazzi, Pierluigi E. ; Fleming, Alfred D. ; Vintzileos, Anthony M. ; Homon, Carol ; Salafia, Carolyn M. / Relationships among cytokines (IL-1, TNF, and IL-8) and histologic markers of acute ascending intrauterine infection. In: Journal of Maternal-Fetal and Neonatal Medicine. 1992 ; Vol. 1, No. 3. pp. 142-147.
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