Relationships among severity of osteonecrosis, pain, range of motion, and functional mobility in children, adolescents, and young adults with acute lymphoblastic leukemia

Victoria G. Marchese, Barbara H. Connolly, Colleen Able, April R. Booten, Patrick Bowen, Bethany M. Porter, Shesh N. Rai, Michael L. Hancock, Ching Hon Pui, Scott Howard, Mike D. Neel, Sue C. Kaste

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background and Purpose: Up to 38% of children receiving treatment for acute lymphoblastic leukemia (ALL) develop osteonecrosis, often without symptoms. Little is known about the association between the degree of osteonecrosis and functional mobility in this population. The purpose of this study was to examine relationships among the degree of osteonecrosis, pain, range of motion (ROM), and functional mobility in people with ALL. Subjects: Thirty-three subjects aged 5 to 27 years with ALL and osteonecrosis participated. Methods: The extent of osteonecrosis was determined by magnetic resonance imaging (MRI) of the hip and knee according to 2 classification systems, including the Association Research Circulation Osseous (ARCO) and a knee staging scale. Pain, hip and knee ROM, and the Timed Up and Down Stairs (TUDS) Test were used as measures. Results: Correlations were observed between ARCO and hip pain (r=.34), between hip flexion ROM and hip pain (r=-.34), and between knee pain and time on the TUDS Test (r=-.35). Discussion and Conclusion: Physical therapists should consider that people with ALL may have hip or knee osteonecrosis without clinical symptoms. This notion supports the need for MRI in addition to a comprehensive examination of functional mobility.

Original languageEnglish (US)
Pages (from-to)341-350
Number of pages10
JournalPhysical Therapy
Volume88
Issue number3
DOIs
StatePublished - Mar 1 2008
Externally publishedYes

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Osteonecrosis
Articular Range of Motion
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hip
Young Adult
Knee
Pain
Magnetic Resonance Imaging
Physical Therapists
Research
Population

All Science Journal Classification (ASJC) codes

  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Relationships among severity of osteonecrosis, pain, range of motion, and functional mobility in children, adolescents, and young adults with acute lymphoblastic leukemia. / Marchese, Victoria G.; Connolly, Barbara H.; Able, Colleen; Booten, April R.; Bowen, Patrick; Porter, Bethany M.; Rai, Shesh N.; Hancock, Michael L.; Pui, Ching Hon; Howard, Scott; Neel, Mike D.; Kaste, Sue C.

In: Physical Therapy, Vol. 88, No. 3, 01.03.2008, p. 341-350.

Research output: Contribution to journalArticle

Marchese, VG, Connolly, BH, Able, C, Booten, AR, Bowen, P, Porter, BM, Rai, SN, Hancock, ML, Pui, CH, Howard, S, Neel, MD & Kaste, SC 2008, 'Relationships among severity of osteonecrosis, pain, range of motion, and functional mobility in children, adolescents, and young adults with acute lymphoblastic leukemia', Physical Therapy, vol. 88, no. 3, pp. 341-350. https://doi.org/10.2522/ptj.20070108
Marchese, Victoria G. ; Connolly, Barbara H. ; Able, Colleen ; Booten, April R. ; Bowen, Patrick ; Porter, Bethany M. ; Rai, Shesh N. ; Hancock, Michael L. ; Pui, Ching Hon ; Howard, Scott ; Neel, Mike D. ; Kaste, Sue C. / Relationships among severity of osteonecrosis, pain, range of motion, and functional mobility in children, adolescents, and young adults with acute lymphoblastic leukemia. In: Physical Therapy. 2008 ; Vol. 88, No. 3. pp. 341-350.
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