Relationships between blood pressure and blood glucose among offspring of parents with type 2 diabetes

Prediction of incident dysglycemia in a biracial cohort

Chimaroke Edeoga, Ibiye Owei, Krishmita Siwakoti, Nkiru Umekwe, Fatoumatta Ceesay, Jim Wan, Samuel Dagogo-Jack

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aims We assessed blood pressure (BP) and blood glucose (BG) values in healthy subjects, and examined baseline BP as a predictor of incident prediabetes during follow-up. Methods Participants in the Pathobiology of Prediabetes in a Biracial Cohort (POP-ABC) study underwent screening assessments (anthropometry, BP, OGTT) and were stratified into normal BP (NBP), prehypertension, or hypertension, and normal glucose regulation (NGR), prediabetes (IFG/IGT), or type 2 diabetes (T2D) status. NGR subjects who met all inclusion criteria were enrolled in a 5-yr prospective study, with the primary outcome of incident prediabetes. Results We screened 602 adults (341 black, 261 white) and enrolled 343 (193 black, 150 white) for prospective follow-up. Systolic and diastolic BP correlated significantly with fasting and nonfasting BG (P = 0.003–< 0.0001). Compared to NGR group, more prediabetic subjects had prehypertension (42.5% vs. 36.2%) and fewer had NBP (35.9% vs. 48.6%) (P = 0.009). During ~ 5 years of follow-up, 26.3% of NBP and 35.7% of prehypertensive subjects developed prediabetes (P = 0.02). Kaplan-Meier analysis showed higher probability of incident prediabetes among participants with prehypertension compared to NBP during ~ 5 years of follow-up (P = 0.0012). Conclusions In our biracial cohort, BP and BG values were significantly correlated, and BP status predicted incident prediabetes among initially normoglycemic individuals. These findings suggest co-evolution of factors involved in the dysregulation of BP and BG.

Original languageEnglish (US)
Pages (from-to)1580-1586
Number of pages7
JournalJournal of Diabetes and its Complications
Volume31
Issue number11
DOIs
StatePublished - Nov 1 2017

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Prediabetic State
Type 2 Diabetes Mellitus
Blood Glucose
Parents
Blood Pressure
Prehypertension
Glucose
Anthropometry
Kaplan-Meier Estimate
Glucose Tolerance Test
Fasting
Healthy Volunteers
Cohort Studies
Prospective Studies
Hypertension

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Relationships between blood pressure and blood glucose among offspring of parents with type 2 diabetes : Prediction of incident dysglycemia in a biracial cohort. / Edeoga, Chimaroke; Owei, Ibiye; Siwakoti, Krishmita; Umekwe, Nkiru; Ceesay, Fatoumatta; Wan, Jim; Dagogo-Jack, Samuel.

In: Journal of Diabetes and its Complications, Vol. 31, No. 11, 01.11.2017, p. 1580-1586.

Research output: Contribution to journalArticle

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title = "Relationships between blood pressure and blood glucose among offspring of parents with type 2 diabetes: Prediction of incident dysglycemia in a biracial cohort",
abstract = "Aims We assessed blood pressure (BP) and blood glucose (BG) values in healthy subjects, and examined baseline BP as a predictor of incident prediabetes during follow-up. Methods Participants in the Pathobiology of Prediabetes in a Biracial Cohort (POP-ABC) study underwent screening assessments (anthropometry, BP, OGTT) and were stratified into normal BP (NBP), prehypertension, or hypertension, and normal glucose regulation (NGR), prediabetes (IFG/IGT), or type 2 diabetes (T2D) status. NGR subjects who met all inclusion criteria were enrolled in a 5-yr prospective study, with the primary outcome of incident prediabetes. Results We screened 602 adults (341 black, 261 white) and enrolled 343 (193 black, 150 white) for prospective follow-up. Systolic and diastolic BP correlated significantly with fasting and nonfasting BG (P = 0.003–< 0.0001). Compared to NGR group, more prediabetic subjects had prehypertension (42.5{\%} vs. 36.2{\%}) and fewer had NBP (35.9{\%} vs. 48.6{\%}) (P = 0.009). During ~ 5 years of follow-up, 26.3{\%} of NBP and 35.7{\%} of prehypertensive subjects developed prediabetes (P = 0.02). Kaplan-Meier analysis showed higher probability of incident prediabetes among participants with prehypertension compared to NBP during ~ 5 years of follow-up (P = 0.0012). Conclusions In our biracial cohort, BP and BG values were significantly correlated, and BP status predicted incident prediabetes among initially normoglycemic individuals. These findings suggest co-evolution of factors involved in the dysregulation of BP and BG.",
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AU - Siwakoti, Krishmita

AU - Umekwe, Nkiru

AU - Ceesay, Fatoumatta

AU - Wan, Jim

AU - Dagogo-Jack, Samuel

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