Relationships between the kallikrein-kinin and prostaglandin systems

A. Nasjletti, Kafait Malik

Research output: Contribution to journalShort survey

87 Citations (Scopus)

Abstract

Kinins are polypeptides released from plasma protein precursor(s) by plasma and tissue enzymes termed kallikreins (1). Bradykinin and kallidin, the peptide products of plasma and glandular kallikreins respectively, exert varied actions on numerous biological systems (2). Two recent findings that suggest interrelation of the kallikrein-kinin and prostaglandin systems have greatly enlarged the potential sphere of influence of kinins. First, bradykinin was shown to stimulate release of prostaglandins (3,4). Second, aspirin-like drugs which are known to antagonize several pharmacological actions of kinins (2) were found to inhibit prostaglandin biosynthesis (5). This led to the proposal that prostaglandins that are released from tissues by kinins contribute to the actions of this class of peptides (4). Interactions of kinins and prostaglandins may be a feature of biological processes as diverse as those involved in inflammatory responses and in regulation of electrolyte and fluid balance (6,7). This review analyzes the relationships between the kallikrein-kinin and prostaglandin systems and discusses the functional significance of such relations.

Original languageEnglish (US)
Pages (from-to)99-109
Number of pages11
JournalLife Sciences
Volume25
Issue number2
DOIs
StatePublished - Jul 9 1979

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Kallikrein-Kinin System
Kinins
Kallikreins
Prostaglandins
Tissue Kallikreins
Water-Electrolyte Balance
Bradykinin
Peptides
Kallidin
Plasma Kallikrein
Biological Phenomena
Tissue
Protein Precursors
Biosynthesis
Aspirin
Biological systems
Blood Proteins
Electrolytes
Pharmacology
Plasmas

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Relationships between the kallikrein-kinin and prostaglandin systems. / Nasjletti, A.; Malik, Kafait.

In: Life Sciences, Vol. 25, No. 2, 09.07.1979, p. 99-109.

Research output: Contribution to journalShort survey

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N2 - Kinins are polypeptides released from plasma protein precursor(s) by plasma and tissue enzymes termed kallikreins (1). Bradykinin and kallidin, the peptide products of plasma and glandular kallikreins respectively, exert varied actions on numerous biological systems (2). Two recent findings that suggest interrelation of the kallikrein-kinin and prostaglandin systems have greatly enlarged the potential sphere of influence of kinins. First, bradykinin was shown to stimulate release of prostaglandins (3,4). Second, aspirin-like drugs which are known to antagonize several pharmacological actions of kinins (2) were found to inhibit prostaglandin biosynthesis (5). This led to the proposal that prostaglandins that are released from tissues by kinins contribute to the actions of this class of peptides (4). Interactions of kinins and prostaglandins may be a feature of biological processes as diverse as those involved in inflammatory responses and in regulation of electrolyte and fluid balance (6,7). This review analyzes the relationships between the kallikrein-kinin and prostaglandin systems and discusses the functional significance of such relations.

AB - Kinins are polypeptides released from plasma protein precursor(s) by plasma and tissue enzymes termed kallikreins (1). Bradykinin and kallidin, the peptide products of plasma and glandular kallikreins respectively, exert varied actions on numerous biological systems (2). Two recent findings that suggest interrelation of the kallikrein-kinin and prostaglandin systems have greatly enlarged the potential sphere of influence of kinins. First, bradykinin was shown to stimulate release of prostaglandins (3,4). Second, aspirin-like drugs which are known to antagonize several pharmacological actions of kinins (2) were found to inhibit prostaglandin biosynthesis (5). This led to the proposal that prostaglandins that are released from tissues by kinins contribute to the actions of this class of peptides (4). Interactions of kinins and prostaglandins may be a feature of biological processes as diverse as those involved in inflammatory responses and in regulation of electrolyte and fluid balance (6,7). This review analyzes the relationships between the kallikrein-kinin and prostaglandin systems and discusses the functional significance of such relations.

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