Release of fibronectin-lipoteichoic acid complexes from group A streptococci with penicillin

T. J. Nealon, E. H. Beachey, H. S. Courtney, W. A. Simpson

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Fibronectin binds to Streptococcus pyogenes, and this binding is inhibited by lipoteichoic acid (LTA). Previous studies have shown that LTA can be released from S. pyogenes by treatment with penicillin. Penicillin released LTA from both S. pyogenes and Staphylococcus aureus; however, the binding of fibronectin correlated with the amount of LTA released only in the case of S. pyogenes. Contrarily, clindamycin decreased the ability of S. aureus to bind fibronectin without affecting the binding of fibronectin to S. pyogenes. Further studies indicated that LTA does not inhibit the binding of fibronectin to S. aureus. Fibronectin bound to S. pyogenes could be released from the cell surface by penicillin. Immunological analysis of the released fibronectin indicated that LTA was the only surface component which could be detected as a soluble complex with the released fibronectin. These studies suggest that LTA plays a central role in the binding of fibronectin to S. pyogenes and is not involved in the binding of fibronectin to S. aureus.

Original languageEnglish (US)
Pages (from-to)529-535
Number of pages7
JournalInfection and Immunity
Volume51
Issue number2
StatePublished - 1986

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Streptococcus
Fibronectins
Penicillins
Streptococcus pyogenes
Staphylococcus aureus
lipoteichoic acid
Clindamycin

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Nealon, T. J., Beachey, E. H., Courtney, H. S., & Simpson, W. A. (1986). Release of fibronectin-lipoteichoic acid complexes from group A streptococci with penicillin. Infection and Immunity, 51(2), 529-535.

Release of fibronectin-lipoteichoic acid complexes from group A streptococci with penicillin. / Nealon, T. J.; Beachey, E. H.; Courtney, H. S.; Simpson, W. A.

In: Infection and Immunity, Vol. 51, No. 2, 1986, p. 529-535.

Research output: Contribution to journalArticle

Nealon, TJ, Beachey, EH, Courtney, HS & Simpson, WA 1986, 'Release of fibronectin-lipoteichoic acid complexes from group A streptococci with penicillin', Infection and Immunity, vol. 51, no. 2, pp. 529-535.
Nealon, T. J. ; Beachey, E. H. ; Courtney, H. S. ; Simpson, W. A. / Release of fibronectin-lipoteichoic acid complexes from group A streptococci with penicillin. In: Infection and Immunity. 1986 ; Vol. 51, No. 2. pp. 529-535.
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