Remission of pre-diabetes to normal glucose tolerance in obese adults with high protein versus high carbohydrate diet

Randomized control trial

Frankie B. Stentz, Amy Brewer, Jim Wan, Channing Garber, Blake Daniels, Chris Sands, Abbas E. Kitabchi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: Remission of pre-diabetes to normal is an important health concern which has had little success in the past. This study objective was to determine the effect on remission of pre-diabetes with a high protein (HP) versus high carbohydrate (HC) diet and effects on metabolic parameters, lean and fat body mass in prediabetic, obese subjects after 6 months of dietary intervention. Research design and methods: We recruited and randomized 24 pre-diabetes women and men to either a HP (30% protein, 30% fat, 40% carbohydrate; n=12) or HC (15% protein, 30% fat, 55% carbohydrate; n=12) diet feeding study for 6 months in this randomized controlled trial. All meals were provided to subjects for 6 months with daily food menus for HP or HC compliance with weekly food pick-up and weight measurements. At baseline and after 6 months on the respective diets oral glucose tolerance and meal tolerance tests were performed with glucose and insulin measurements and dual energy X-ray absorptiometry scans. Results: After 6 months on the HP diet, 100% of the subjects had remission of their pre-diabetes to normal glucose tolerance, whereas only 33.3% of subjects on the HC diet had remission of their pre-diabetes. The HP diet group exhibited significant improvement in (1) insulin sensitivity (p=0.001), (2) cardiovascular risk factors (p=0.04), (3) inflammatory cytokines (p=0.001), (4) oxidative stress (p=0.001), (5) increased percent lean body mass (p=0.001) compared with the HC diet at 6 months. Conclusions: This is the first dietary intervention feeding study, to the best of our knowledge, to report 100% remission of pre-diabetes with a HP diet and significant improvement in metabolic parameters and anti-inflammatory effects compared with a HC diet at 6 months.

Original languageEnglish (US)
Article numbere000258
JournalBMJ Open Diabetes Research and Care
Volume4
Issue number1
DOIs
StatePublished - Oct 1 2016

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Carbohydrates
Diet
Glucose
Proteins
Meals
Fats
Food
Fat Body
Photon Absorptiometry
Glucose Tolerance Test
Insulin Resistance
Oxidative Stress
Anti-Inflammatory Agents
Research Design
Randomized Controlled Trials
Insulin
Cytokines
Weights and Measures
Health

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

Cite this

Remission of pre-diabetes to normal glucose tolerance in obese adults with high protein versus high carbohydrate diet : Randomized control trial. / Stentz, Frankie B.; Brewer, Amy; Wan, Jim; Garber, Channing; Daniels, Blake; Sands, Chris; Kitabchi, Abbas E.

In: BMJ Open Diabetes Research and Care, Vol. 4, No. 1, e000258, 01.10.2016.

Research output: Contribution to journalArticle

Stentz, Frankie B. ; Brewer, Amy ; Wan, Jim ; Garber, Channing ; Daniels, Blake ; Sands, Chris ; Kitabchi, Abbas E. / Remission of pre-diabetes to normal glucose tolerance in obese adults with high protein versus high carbohydrate diet : Randomized control trial. In: BMJ Open Diabetes Research and Care. 2016 ; Vol. 4, No. 1.
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AB - Objective: Remission of pre-diabetes to normal is an important health concern which has had little success in the past. This study objective was to determine the effect on remission of pre-diabetes with a high protein (HP) versus high carbohydrate (HC) diet and effects on metabolic parameters, lean and fat body mass in prediabetic, obese subjects after 6 months of dietary intervention. Research design and methods: We recruited and randomized 24 pre-diabetes women and men to either a HP (30% protein, 30% fat, 40% carbohydrate; n=12) or HC (15% protein, 30% fat, 55% carbohydrate; n=12) diet feeding study for 6 months in this randomized controlled trial. All meals were provided to subjects for 6 months with daily food menus for HP or HC compliance with weekly food pick-up and weight measurements. At baseline and after 6 months on the respective diets oral glucose tolerance and meal tolerance tests were performed with glucose and insulin measurements and dual energy X-ray absorptiometry scans. Results: After 6 months on the HP diet, 100% of the subjects had remission of their pre-diabetes to normal glucose tolerance, whereas only 33.3% of subjects on the HC diet had remission of their pre-diabetes. The HP diet group exhibited significant improvement in (1) insulin sensitivity (p=0.001), (2) cardiovascular risk factors (p=0.04), (3) inflammatory cytokines (p=0.001), (4) oxidative stress (p=0.001), (5) increased percent lean body mass (p=0.001) compared with the HC diet at 6 months. Conclusions: This is the first dietary intervention feeding study, to the best of our knowledge, to report 100% remission of pre-diabetes with a HP diet and significant improvement in metabolic parameters and anti-inflammatory effects compared with a HC diet at 6 months.

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