Remodeling of the rat right and left ventricles in experimental hypertension

C. G. Brilla, R. Pick, L. B. Tan, J. S. Janicki, Karl Weber

Research output: Contribution to journalArticle

648 Citations (Scopus)

Abstract

Pathological left ventricular hypertrophy in renovascular hypertension is associated with the accumulation of fibrillar collagen within the extracellular space and around intramyocardial coronary arteries. Even though the angiotensin converting enzyme inhibitor captopril was previously found to attenuate this interstitial and perivascular fibrosis, the relative importance of arterial and ventricular systolic pressures versus circulating angiotensin II (AII) and aldosterone (AL) in promoting hypertrophy and collagen accumulation in renovascular hypertension is uncertain. By drawing on the in-parallel arrangement of the right and left ventricles, with respect to their coronary circulation, and the in-series mechanical alignment of the ventricles, with a pressure-overloaded left and a normotensive right ventricle, this study sought to address this uncertainty. Three models of experimental hypertension, each having a different circulating AII and AL profile, were examined and compared with their controls: renovascular hypertension, where both AII and AL are increased; infrarenal aorta banding, where AII and AL are normal; and a chronic infusion of AL, where AII is suppressed or normal and AL is increased. In renovascular hypertension, as well as with AL, we found a significant rise in the interstitial collagen volume fraction and perivascular collagen area of the pressure-overloaded, hypertrophied left ventricle as well as the normotensive, nonhypertrophied right ventricle. This remodeling was not seen in either ventricle with infrarenal aorta banding despite comparable systemic hypertension and left ventricular hypertrophy. Thus, in experimental arterial hypertension in the rat, myocyte and nonmyocyte compartments of the myocardium are under separate controls: myocyte hypertrophy is most closely related to ventricular loading while circulating AII and AL, acting alone or in concert with other humoral factors, regulate the accumulation of collagen within the rigth and left ventricles.

Original languageEnglish (US)
Pages (from-to)1355-1364
Number of pages10
JournalCirculation research
Volume67
Issue number6
DOIs
StatePublished - Jan 1 1990

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Aldosterone
Heart Ventricles
Angiotensin II
Hypertension
Renovascular Hypertension
Collagen
Left Ventricular Hypertrophy
Muscle Cells
Hypertrophy
Aorta
Fibrillar Collagens
Pressure
Coronary Circulation
Captopril
Extracellular Space
Ventricular Pressure
Angiotensin-Converting Enzyme Inhibitors
Uncertainty
Coronary Vessels
Myocardium

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Remodeling of the rat right and left ventricles in experimental hypertension. / Brilla, C. G.; Pick, R.; Tan, L. B.; Janicki, J. S.; Weber, Karl.

In: Circulation research, Vol. 67, No. 6, 01.01.1990, p. 1355-1364.

Research output: Contribution to journalArticle

Brilla, C. G. ; Pick, R. ; Tan, L. B. ; Janicki, J. S. ; Weber, Karl. / Remodeling of the rat right and left ventricles in experimental hypertension. In: Circulation research. 1990 ; Vol. 67, No. 6. pp. 1355-1364.
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