Renal carcinoma after childhood cancer

A report from the childhood cancer survivor study

Carmen L. Wilson, Kirsten K. Ness, Joseph P. Neglia, Sue Hammond, Margarett Shnorhavorian, Wendy L. Leisenring, Marilyn Stovall, Leslie L. Robison, Gregory Armstrong

Research output: Contribution to journalArticle

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Abstract

Adult survivors of childhood cancer are known to be at increased risk of subsequent malignancy, but only limited data exist describing the incidence and risk factors for secondary renal carcinoma. Among 14 358 5-year survivors diagnosed between 1970 and 1986, we estimated standardized incidence ratios (SIRs) for subsequent renal carcinoma and identified associations with primary cancer therapy using Poisson regression. Twenty-six survivors were diagnosed with renal carcinoma (median = 22.6 years from diagnosis; range = 6.3-35.7 years), reflecting a statistically significant excess (SIR = 8.0, 95% confidence interval [CI] = 5.2 to 11.7) compared with the general population. Highest risk was observed among neuroblastoma survivors (SIR = 85.8, 95% CI = 38.4 to 175.2) and, in multivariable analyses, with renal-directed radiotherapy of 5 Gy or greater (relative risk [RR] = 3.8, 95% CI = 1.6 to 9.3) and platinum-based chemotherapy (RR = 3.5, 95% CI = 1.0 to 11.2). To our knowledge, this is the first report of an association between cisplatin and subsequent renal carcinoma among survivors of childhood cancer.

Original languageEnglish (US)
Pages (from-to)504-508
Number of pages5
JournalJournal of the National Cancer Institute
Volume105
Issue number7
DOIs
StatePublished - Apr 3 2013
Externally publishedYes

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Carcinoma
Kidney
Confidence Intervals
Incidence
Neoplasms
Platinum
Neuroblastoma
Cisplatin
Radiotherapy
Drug Therapy
Population
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Wilson, C. L., Ness, K. K., Neglia, J. P., Hammond, S., Shnorhavorian, M., Leisenring, W. L., ... Armstrong, G. (2013). Renal carcinoma after childhood cancer: A report from the childhood cancer survivor study. Journal of the National Cancer Institute, 105(7), 504-508. https://doi.org/10.1093/jnci/djt014

Renal carcinoma after childhood cancer : A report from the childhood cancer survivor study. / Wilson, Carmen L.; Ness, Kirsten K.; Neglia, Joseph P.; Hammond, Sue; Shnorhavorian, Margarett; Leisenring, Wendy L.; Stovall, Marilyn; Robison, Leslie L.; Armstrong, Gregory.

In: Journal of the National Cancer Institute, Vol. 105, No. 7, 03.04.2013, p. 504-508.

Research output: Contribution to journalArticle

Wilson, CL, Ness, KK, Neglia, JP, Hammond, S, Shnorhavorian, M, Leisenring, WL, Stovall, M, Robison, LL & Armstrong, G 2013, 'Renal carcinoma after childhood cancer: A report from the childhood cancer survivor study', Journal of the National Cancer Institute, vol. 105, no. 7, pp. 504-508. https://doi.org/10.1093/jnci/djt014
Wilson CL, Ness KK, Neglia JP, Hammond S, Shnorhavorian M, Leisenring WL et al. Renal carcinoma after childhood cancer: A report from the childhood cancer survivor study. Journal of the National Cancer Institute. 2013 Apr 3;105(7):504-508. https://doi.org/10.1093/jnci/djt014
Wilson, Carmen L. ; Ness, Kirsten K. ; Neglia, Joseph P. ; Hammond, Sue ; Shnorhavorian, Margarett ; Leisenring, Wendy L. ; Stovall, Marilyn ; Robison, Leslie L. ; Armstrong, Gregory. / Renal carcinoma after childhood cancer : A report from the childhood cancer survivor study. In: Journal of the National Cancer Institute. 2013 ; Vol. 105, No. 7. pp. 504-508.
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