Renal enzyme activities in experimental ochratoxin a-induced porcine nephropathy

Diagnostic potential of phosphoenolpyruvate carboxyk1nase and gamma-glutamyl transpeptidase activity

Palle Krogh, Nils Gyrd-Hansen, Benedicte Hatd, Steen Larsen, Jens Peter Nielsen, Mogens Smith, Chris Ivanoff, Herman Meisner

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Enzyme activities have been measured in needle biopsies from kidneys of pigs fed 1 ppm or 0.2 ppm of ochratoxin A for 1-5 wks. After feeding 1 ppm toxin for 1 wk, the activity of cytosolic phosphoenolpyruvate carboxykinase (PEPCK) was decreased by 40% and remained inhibited until the termination of the experiment (5 wk). The activity of gamma-glutamyl transpeptidase, a brush-border enzyme found in the proximal tubules, was reduced to a similar degree and remained inhibited. The activities of hexokinase, a cytosolic enzyme of general distribution in the nephron, and phosphate-dependent.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalJournal of Toxicology and Environmental Health
Volume23
Issue number1
DOIs
StatePublished - Jan 1 1988

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Ochratoxins
Phosphoenolpyruvate
gamma-Glutamyltransferase
Enzyme activity
Swine
Enzymes
Kidney
Hexokinase
Biopsy
Brushes
Needles
Phosphates
Nephrons
Needle Biopsy
Microvilli
Experiments
ochratoxin A

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pollution

Cite this

Renal enzyme activities in experimental ochratoxin a-induced porcine nephropathy : Diagnostic potential of phosphoenolpyruvate carboxyk1nase and gamma-glutamyl transpeptidase activity. / Krogh, Palle; Gyrd-Hansen, Nils; Hatd, Benedicte; Larsen, Steen; Nielsen, Jens Peter; Smith, Mogens; Ivanoff, Chris; Meisner, Herman.

In: Journal of Toxicology and Environmental Health, Vol. 23, No. 1, 01.01.1988, p. 1-14.

Research output: Contribution to journalArticle

Krogh, Palle ; Gyrd-Hansen, Nils ; Hatd, Benedicte ; Larsen, Steen ; Nielsen, Jens Peter ; Smith, Mogens ; Ivanoff, Chris ; Meisner, Herman. / Renal enzyme activities in experimental ochratoxin a-induced porcine nephropathy : Diagnostic potential of phosphoenolpyruvate carboxyk1nase and gamma-glutamyl transpeptidase activity. In: Journal of Toxicology and Environmental Health. 1988 ; Vol. 23, No. 1. pp. 1-14.
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