Renal involvement in tuberous sclerosis complex and von Hippel-Lindau disease: Shared disease mechanisms?

Brian J. Siroky, Maria F. Czyzyk-Krzeska, John Bissler

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Tuberous sclerosis complex and von Hippel-Lindau disease are distinct autosomal dominant tumor suppressor syndromes that can exhibit similar renal phenotypes and seem to share some signaling pathway components. Similarities exist in the current clinical management of, and the newly identified potential therapeutic approaches for, these conditions. This Review summarizes the pathophysiologic and therapeutic overlap between tuberous sclerosis complex and von Hippel-Lindau disease and highlights the results of recent drug trials in these settings.

Original languageEnglish (US)
Pages (from-to)143-156
Number of pages14
JournalNature Clinical Practice Nephrology
Volume5
Issue number3
DOIs
StatePublished - Mar 1 2009

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von Hippel-Lindau Disease
Tuberous Sclerosis
Kidney
Phenotype
Therapeutics
Pharmaceutical Preparations
Neoplasms

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Renal involvement in tuberous sclerosis complex and von Hippel-Lindau disease : Shared disease mechanisms? / Siroky, Brian J.; Czyzyk-Krzeska, Maria F.; Bissler, John.

In: Nature Clinical Practice Nephrology, Vol. 5, No. 3, 01.03.2009, p. 143-156.

Research output: Contribution to journalReview article

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