Renal oncocytosis: A morphologic study of fourteen cases

Satish K. Tickoo, Victor E. Reuter, Mahul Amin, John R. Srigley, Jonathan I. Epstein, Kyung Whan Min, Mark A. Rubin, Jae Y. Ro

Research output: Contribution to journalArticle

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Abstract

Diffuse renal involvement by numerous oncocytic nodules has rarely been described. We report 14 cases (19 specimens) with innumerable oncocytic nodules in the kidney. Invariably, these kidneys showed additional associated findings. We suggest the term renal oncocytosis for this entire morphologic spectrum. Six (43%) cases had histologically or radiologically proven bilateral involvement. Each specimen had at least one dominant tumor (2.0- 10.5 cm) in addition to numerous other microscopic to macroscopic oncocytic nodules. Additional features observed were: interstitial pattern, with the oncocytic tubules and acini diffusely intermingling with and infiltrating between nonneoplastic parenchyma (one case); diffuse oncocytic change in the nonneoplastic tubules, cytologically difficult to separate from the oncocytic nodules (seven cases); and benign oncocytic cortical cysts (four cases). The dominant mass in 13 specimens was a renal oncocytoma and in two, a chromophobe renal cell carcinoma. In four specimens, the largest tumor was considered a hybrid tumor because of the presence of mixed histologic features of both tumor types. Most smaller nodules had the morphologic features of renal oncocytoma, but a few had the appearance of chromophobe renal cell carcinoma or nodules with hybrid features. We conclude that the presence of numerous oncocytic nodules may be associated with a wide spectrum of oncocytic changes in the kidney. The association of numerous renal oncocytoma-like nodules with lesions having a mixed morphology or a morphology of pure chromophobe renal cell carcinoma suggests that they may constitute a morphologic spectrum of oncocytic tumors and that renal oncocytoma and chromophobe renal cell carcinoma may arise from a common progenitor lesion.

Original languageEnglish (US)
Pages (from-to)1094-1101
Number of pages8
JournalAmerican Journal of Surgical Pathology
Volume23
Issue number9
DOIs
StatePublished - Sep 1 1999

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Renal Cell Carcinoma
Kidney
Neoplasms
Cysts
Renal oncocytoma

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Tickoo, S. K., Reuter, V. E., Amin, M., Srigley, J. R., Epstein, J. I., Min, K. W., ... Ro, J. Y. (1999). Renal oncocytosis: A morphologic study of fourteen cases. American Journal of Surgical Pathology, 23(9), 1094-1101. https://doi.org/10.1097/00000478-199909000-00013

Renal oncocytosis : A morphologic study of fourteen cases. / Tickoo, Satish K.; Reuter, Victor E.; Amin, Mahul; Srigley, John R.; Epstein, Jonathan I.; Min, Kyung Whan; Rubin, Mark A.; Ro, Jae Y.

In: American Journal of Surgical Pathology, Vol. 23, No. 9, 01.09.1999, p. 1094-1101.

Research output: Contribution to journalArticle

Tickoo, SK, Reuter, VE, Amin, M, Srigley, JR, Epstein, JI, Min, KW, Rubin, MA & Ro, JY 1999, 'Renal oncocytosis: A morphologic study of fourteen cases', American Journal of Surgical Pathology, vol. 23, no. 9, pp. 1094-1101. https://doi.org/10.1097/00000478-199909000-00013
Tickoo, Satish K. ; Reuter, Victor E. ; Amin, Mahul ; Srigley, John R. ; Epstein, Jonathan I. ; Min, Kyung Whan ; Rubin, Mark A. ; Ro, Jae Y. / Renal oncocytosis : A morphologic study of fourteen cases. In: American Journal of Surgical Pathology. 1999 ; Vol. 23, No. 9. pp. 1094-1101.
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