Renal pathology resulting from PGHS-2 gene ablation in DBA/B6 mice

Stanley J.F. Laulederkind, Barry Wall, Leslie R. Ballou, Rajendra Raghow

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Kidneys of prostaglandin H synthase-2 (PGHS-2) null mice fail to develop normally, leading to renal insufficiency. We have found that in a mixed DBA/B6 background, the lack of a functional PGHS-2 gene causes less severe renal pathology than was reported previously for PGHS-2 null mice in a B6 genetic background. The increase in blood urea nitrogen in the DBA/B6 strain of PGHS-2 null mice was significantly lower than reported for B6 PGHS-2 null mice (200% versus 270%). Cystic changes in DBA/B6 PGHS-2 null mice were also less severe. The DBA/B6 PGHS-2 null adult mice did not die from renal failure, unlike their B6/PGHS-2 counterparts that showed excessive neonatal and adult deaths. Therefore, DBA/B6 PGHS-2 null may be highly suitable to study the functional consequences of the lack of PGHS-2 in the kidney due to their less severe pathology and greater survival.

Original languageEnglish (US)
Pages (from-to)161-168
Number of pages8
JournalProstaglandins and Other Lipid Mediators
Volume70
Issue number1-2
DOIs
StatePublished - Sep 1 2002

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Inbred DBA Mouse
Pathology
Cyclooxygenase 2
Ablation
Genes
Kidney
Renal Insufficiency
Blood Urea Nitrogen
Urea
Blood
Nitrogen

All Science Journal Classification (ASJC) codes

  • Physiology
  • Biochemistry
  • Pharmacology
  • Cell Biology

Cite this

Renal pathology resulting from PGHS-2 gene ablation in DBA/B6 mice. / Laulederkind, Stanley J.F.; Wall, Barry; Ballou, Leslie R.; Raghow, Rajendra.

In: Prostaglandins and Other Lipid Mediators, Vol. 70, No. 1-2, 01.09.2002, p. 161-168.

Research output: Contribution to journalArticle

Laulederkind, Stanley J.F. ; Wall, Barry ; Ballou, Leslie R. ; Raghow, Rajendra. / Renal pathology resulting from PGHS-2 gene ablation in DBA/B6 mice. In: Prostaglandins and Other Lipid Mediators. 2002 ; Vol. 70, No. 1-2. pp. 161-168.
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