Renal prostaglandins.

N. A. Terragno, Kafait Malik, A. Nasjletti, D. A. Terragno, J. C. McGiff

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

1. Renal prostaglandins act primarily as local hormones, having their effects at, or near to, sites of synthesis. PGE2 is a major determinant of renal vascular reactivity; it opposes the vasoconstrictor and natriuretic actions of pressor hormones and brakes the release of noradrenaline from adrenergic nerves. In the unanaesthetized rabbit prolonged inhibition of prostaglandin synthesis results in hypertension. In the rat, however, renal prostaglandins augment pressor stimuli. 2. Basal efflux of renal prostaglandins is positively correlated with blood flow to the inner cortex and medulla. Those stimuli which increase renal medullary blood flow do so primarily by activating prostaglandin synthetase. 3. Kinins increase prostaglandin synthesis which action modifies the renal effects of kinins. Thus, one or more renal prostaglandins contribute to the renal vasodilator action of bradykinin and mediate its effect on excretion of water as well as possibly attenuating the natriuretic action of the polypeptide. Kinins in addition to stimulating prostaglandin synthesis may determine the principal product of synthetase by regulating the enzyme PGE 9-ketoreductase, which converts PGE to PGF. The coupling of these systems within the kidney appears unique--prostaglandins mediate some of the actions of kinins and modulate others, whereas they depend on the intrarenal generation of kinins to set their level and type of activity.

Original languageEnglish (US)
Pages (from-to)561-571
Number of pages11
JournalAdvances in prostaglandin and thromboxane research
Volume2
StatePublished - 1976

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Prostaglandins
Kinins
Kidney
prostaglandin-E2 9-reductase
Hormones
Renal Circulation
Prostaglandins F
Bradykinin
Vasoconstrictor Agents
Prostaglandin-Endoperoxide Synthases
Ligases
Prostaglandins E
Vasodilator Agents
Dinoprostone
Adrenergic Agents
Blood Vessels
Norepinephrine
Rabbits
Hypertension
Peptides

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Terragno, N. A., Malik, K., Nasjletti, A., Terragno, D. A., & McGiff, J. C. (1976). Renal prostaglandins. Advances in prostaglandin and thromboxane research, 2, 561-571.

Renal prostaglandins. / Terragno, N. A.; Malik, Kafait; Nasjletti, A.; Terragno, D. A.; McGiff, J. C.

In: Advances in prostaglandin and thromboxane research, Vol. 2, 1976, p. 561-571.

Research output: Contribution to journalReview article

Terragno, NA, Malik, K, Nasjletti, A, Terragno, DA & McGiff, JC 1976, 'Renal prostaglandins.', Advances in prostaglandin and thromboxane research, vol. 2, pp. 561-571.
Terragno NA, Malik K, Nasjletti A, Terragno DA, McGiff JC. Renal prostaglandins. Advances in prostaglandin and thromboxane research. 1976;2:561-571.
Terragno, N. A. ; Malik, Kafait ; Nasjletti, A. ; Terragno, D. A. ; McGiff, J. C. / Renal prostaglandins. In: Advances in prostaglandin and thromboxane research. 1976 ; Vol. 2. pp. 561-571.
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