Renin-angiotensin system and myocardial fibrosis in hypertension: Regulation of the myocardial collagen matrix

C. G. Brilla, G. P. Reams, B. Maisch, Karl Weber

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

The cardiac interstitium is composed of non-myocyte cells embedded in a highly organized extracellular matrix containing a three-dimensional collagen network which serves to maintain the architecture of the myocardium and determines myocardial stiffness In hypertensive heart disease, a heterogeneity in myocardial structure, created by the altered behaviour of cardiac fibroblasts responsible for collagen synthesis and degradation, can explain the appearance of diastolic and ultimately systolic dysfunction of the left ventricle. In vivo, circulating and myocardial renin-angiotensin systems (RAS) were found to be involved in the regulation of the structural remodelling of the cardiac interstitium. In vitro, in cultured adult rat cardiac fibroblasts, angiotensin II was shown to stimulate collagen synthesis and to inhibit collagenase activity, which is the key enzyme for collagen degradation. In the SHR-model of primary hypertension, left ventricular hypertrophy could be regressed and abnormal myocardial diastolic stiffness, due to interstitial fibrosis, could be restored to normal by inhibition of the myocardial RAS. These antifibrotic or cardioreparative effects of ACE inhibition that occurred irrespective of blood pressure normalization may be valuable in reversing left ventricular diastolic dysfunction in hypertensive heart disease.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalEuropean Heart Journal
Volume14
Issue numberSUPPL. J
StatePublished - Jan 1 1993

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Renin-Angiotensin System
Fibrosis
Collagen
Hypertension
Heart Diseases
Fibroblasts
Left Ventricular Dysfunction
Left Ventricular Hypertrophy
Collagenases
Angiotensin II
Heart Ventricles
Extracellular Matrix
Myocardium
Blood Pressure
Enzymes
Inhibition (Psychology)

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Renin-angiotensin system and myocardial fibrosis in hypertension : Regulation of the myocardial collagen matrix. / Brilla, C. G.; Reams, G. P.; Maisch, B.; Weber, Karl.

In: European Heart Journal, Vol. 14, No. SUPPL. J, 01.01.1993, p. 57-61.

Research output: Contribution to journalArticle

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