Repeated dosing of digoxin-fragmented antibody in preterm eclampsia

Charles Adair, V. M. Buckalew, J. Kipikasa, C. Torres, S. P. Stallings, C. M. Briery

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Early onset eclampsia has significant morbidity and mortality for both the mother and fetus. No effective treatment exists at present except delivery and seizure prophylaxis with magnesium sulfate. We report the novel use of a fragmented ovine antibody against digoxin for the treatment of eclampsia. A 16-year-old primagravida at 29 weeks 5/7 days gestation presented with clinical diagnosis of eclampsia and was treated with compassionate off-label use of digoxin-fragmented ovine antibody (Digibind Glaxo Smith Kline, Research Triangle Park, NC, USA). Improvement of her underlying disorder during a 48h treatment window was noted without adverse maternal or neonatal outcome. We suggest digoxin-fragmented ovine antibody as a possible intervention in preterm pregnancies complicated by pre-eclampsia or eclampsia.

Original languageEnglish (US)
Pages (from-to)163-165
Number of pages3
JournalJournal of Perinatology
Volume29
Issue number2
DOIs
StatePublished - Feb 11 2009

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Eclampsia
Digoxin
Sheep
Antibodies
Compassionate Use Trials
Mothers
Off-Label Use
Pregnancy
Magnesium Sulfate
Pre-Eclampsia
Seizures
Fetus
Therapeutics
Morbidity
Mortality
Research

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Adair, C., Buckalew, V. M., Kipikasa, J., Torres, C., Stallings, S. P., & Briery, C. M. (2009). Repeated dosing of digoxin-fragmented antibody in preterm eclampsia. Journal of Perinatology, 29(2), 163-165. https://doi.org/10.1038/jp.2008.181

Repeated dosing of digoxin-fragmented antibody in preterm eclampsia. / Adair, Charles; Buckalew, V. M.; Kipikasa, J.; Torres, C.; Stallings, S. P.; Briery, C. M.

In: Journal of Perinatology, Vol. 29, No. 2, 11.02.2009, p. 163-165.

Research output: Contribution to journalArticle

Adair, C, Buckalew, VM, Kipikasa, J, Torres, C, Stallings, SP & Briery, CM 2009, 'Repeated dosing of digoxin-fragmented antibody in preterm eclampsia', Journal of Perinatology, vol. 29, no. 2, pp. 163-165. https://doi.org/10.1038/jp.2008.181
Adair C, Buckalew VM, Kipikasa J, Torres C, Stallings SP, Briery CM. Repeated dosing of digoxin-fragmented antibody in preterm eclampsia. Journal of Perinatology. 2009 Feb 11;29(2):163-165. https://doi.org/10.1038/jp.2008.181
Adair, Charles ; Buckalew, V. M. ; Kipikasa, J. ; Torres, C. ; Stallings, S. P. ; Briery, C. M. / Repeated dosing of digoxin-fragmented antibody in preterm eclampsia. In: Journal of Perinatology. 2009 ; Vol. 29, No. 2. pp. 163-165.
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