Repeated exposure to inhaled toluene induces behavioral and neurochemical cross-sensitization to cocaine in rats

C. E. Beyer, D. Stafford, M. G. LeSage, J. R. Glowa, Jeffery Steketee

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Rationale: Toluene is a solvent found in many commercial products and is frequently abused by inhalation. Whether previous exposure to toluene alters subsequent responses to other drugs of abuse is not known. Objectives: This study determined the effects of repeated toluene exposure on the acute motor-stimulant response to cocaine and on cocaine-induced dopamine (DA) concentrations in the nucleus accumbens (NAc). Methods: One week following bilateral cannulae implantation over the NAc, 27 adult, male Wistar rats began a daily 30-min exposure regimen to either toluene (8000 ppm) or air for ten sessions. Approximately 24 h or 96 h after their last exposure, animals were injected with either saline or cocaine (15 mg/kg, i.p.) and locomotor activity and DA concentrations in the NAc were measured. Results: Exposure to toluene rendered the rats immobile, and the time required for recovery of normal posture decreased across the ten sessions. In all animals tested, systemic cocaine administration enhanced both locomotor activity and DA concentrations in the NAc. These increases, however, were significantly greater in rats previously exposed to toluene. Conclusions: Overall, these findings show that repeated toluene exposure enhances behavioral and neurochemical responses to subsequent cocaine administration.

Original languageEnglish (US)
Pages (from-to)198-204
Number of pages7
JournalPsychopharmacology
Volume154
Issue number2
DOIs
StatePublished - Jan 1 2001

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Toluene
Cocaine
Nucleus Accumbens
Dopamine
Locomotion
Street Drugs
Posture
Inhalation
Wistar Rats
Air

All Science Journal Classification (ASJC) codes

  • Pharmacology

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Repeated exposure to inhaled toluene induces behavioral and neurochemical cross-sensitization to cocaine in rats. / Beyer, C. E.; Stafford, D.; LeSage, M. G.; Glowa, J. R.; Steketee, Jeffery.

In: Psychopharmacology, Vol. 154, No. 2, 01.01.2001, p. 198-204.

Research output: Contribution to journalArticle

Beyer, C. E. ; Stafford, D. ; LeSage, M. G. ; Glowa, J. R. ; Steketee, Jeffery. / Repeated exposure to inhaled toluene induces behavioral and neurochemical cross-sensitization to cocaine in rats. In: Psychopharmacology. 2001 ; Vol. 154, No. 2. pp. 198-204.
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