Report and recommendations of the workshop of the European centre for the validation of alternative methods for drug-induced cardiotoxicity

Tina C. Stummann, Mario Beilmann, Göran Duker, Berengere Dumotier, J. Magnus Fredriksson, Robin L. Jones, Marina Hasiwa, Yujian Kang, Carl Fredrik Mandenius, Thomas Meyer, Giorgio Minotti, Y. Jean Pierre Valentin, Bernd J. Zünkler, Susanne Bremer

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Cardiotoxicity is among the leading reasons for drug attrition and is therefore a core subject in non-clinical and clinical safety testing of new drugs. European Centre for the Validation of Alternative Methods held in March 2008 a workshop on "Alternative Methods for Drug-induced Cardiotoxicity" in order to promote acceptance of alternative methods reducing, refining or replacing the use of laboratory animals in this field. This review reports the outcome of the workshop. The participants identified the major clinical manifestations, which are sensitive to conventional drugs, to be arrhythmias, contractility toxicity, ischaemia toxicity, secondary cardiotoxicity and valve toxicity. They gave an overview of the current use of alternative tests in cardiac safety assessments. Moreover, they elaborated on new cardiotoxicological endpoints for which alternative tests can have an impact and provided recommendations on how to cover them.

Original languageEnglish (US)
Pages (from-to)107-125
Number of pages19
JournalCardiovascular Toxicology
Volume9
Issue number3
DOIs
StatePublished - Sep 1 2009

Fingerprint

Toxicity
Education
Pharmaceutical Preparations
Safety testing
Safety
Laboratory Animals
Refining
Cardiac Arrhythmias
Animals
Ischemia
Cardiotoxicity

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Toxicology
  • Cardiology and Cardiovascular Medicine

Cite this

Report and recommendations of the workshop of the European centre for the validation of alternative methods for drug-induced cardiotoxicity. / Stummann, Tina C.; Beilmann, Mario; Duker, Göran; Dumotier, Berengere; Fredriksson, J. Magnus; Jones, Robin L.; Hasiwa, Marina; Kang, Yujian; Mandenius, Carl Fredrik; Meyer, Thomas; Minotti, Giorgio; Valentin, Y. Jean Pierre; Zünkler, Bernd J.; Bremer, Susanne.

In: Cardiovascular Toxicology, Vol. 9, No. 3, 01.09.2009, p. 107-125.

Research output: Contribution to journalArticle

Stummann, TC, Beilmann, M, Duker, G, Dumotier, B, Fredriksson, JM, Jones, RL, Hasiwa, M, Kang, Y, Mandenius, CF, Meyer, T, Minotti, G, Valentin, YJP, Zünkler, BJ & Bremer, S 2009, 'Report and recommendations of the workshop of the European centre for the validation of alternative methods for drug-induced cardiotoxicity', Cardiovascular Toxicology, vol. 9, no. 3, pp. 107-125. https://doi.org/10.1007/s12012-009-9045-3
Stummann, Tina C. ; Beilmann, Mario ; Duker, Göran ; Dumotier, Berengere ; Fredriksson, J. Magnus ; Jones, Robin L. ; Hasiwa, Marina ; Kang, Yujian ; Mandenius, Carl Fredrik ; Meyer, Thomas ; Minotti, Giorgio ; Valentin, Y. Jean Pierre ; Zünkler, Bernd J. ; Bremer, Susanne. / Report and recommendations of the workshop of the European centre for the validation of alternative methods for drug-induced cardiotoxicity. In: Cardiovascular Toxicology. 2009 ; Vol. 9, No. 3. pp. 107-125.
@article{8232dd1561334379bca0ccfcc017b2d8,
title = "Report and recommendations of the workshop of the European centre for the validation of alternative methods for drug-induced cardiotoxicity",
abstract = "Cardiotoxicity is among the leading reasons for drug attrition and is therefore a core subject in non-clinical and clinical safety testing of new drugs. European Centre for the Validation of Alternative Methods held in March 2008 a workshop on {"}Alternative Methods for Drug-induced Cardiotoxicity{"} in order to promote acceptance of alternative methods reducing, refining or replacing the use of laboratory animals in this field. This review reports the outcome of the workshop. The participants identified the major clinical manifestations, which are sensitive to conventional drugs, to be arrhythmias, contractility toxicity, ischaemia toxicity, secondary cardiotoxicity and valve toxicity. They gave an overview of the current use of alternative tests in cardiac safety assessments. Moreover, they elaborated on new cardiotoxicological endpoints for which alternative tests can have an impact and provided recommendations on how to cover them.",
author = "Stummann, {Tina C.} and Mario Beilmann and G{\"o}ran Duker and Berengere Dumotier and Fredriksson, {J. Magnus} and Jones, {Robin L.} and Marina Hasiwa and Yujian Kang and Mandenius, {Carl Fredrik} and Thomas Meyer and Giorgio Minotti and Valentin, {Y. Jean Pierre} and Z{\"u}nkler, {Bernd J.} and Susanne Bremer",
year = "2009",
month = "9",
day = "1",
doi = "10.1007/s12012-009-9045-3",
language = "English (US)",
volume = "9",
pages = "107--125",
journal = "Cardiovascular Toxicology",
issn = "1530-7905",
publisher = "Humana Press",
number = "3",

}

TY - JOUR

T1 - Report and recommendations of the workshop of the European centre for the validation of alternative methods for drug-induced cardiotoxicity

AU - Stummann, Tina C.

AU - Beilmann, Mario

AU - Duker, Göran

AU - Dumotier, Berengere

AU - Fredriksson, J. Magnus

AU - Jones, Robin L.

AU - Hasiwa, Marina

AU - Kang, Yujian

AU - Mandenius, Carl Fredrik

AU - Meyer, Thomas

AU - Minotti, Giorgio

AU - Valentin, Y. Jean Pierre

AU - Zünkler, Bernd J.

AU - Bremer, Susanne

PY - 2009/9/1

Y1 - 2009/9/1

N2 - Cardiotoxicity is among the leading reasons for drug attrition and is therefore a core subject in non-clinical and clinical safety testing of new drugs. European Centre for the Validation of Alternative Methods held in March 2008 a workshop on "Alternative Methods for Drug-induced Cardiotoxicity" in order to promote acceptance of alternative methods reducing, refining or replacing the use of laboratory animals in this field. This review reports the outcome of the workshop. The participants identified the major clinical manifestations, which are sensitive to conventional drugs, to be arrhythmias, contractility toxicity, ischaemia toxicity, secondary cardiotoxicity and valve toxicity. They gave an overview of the current use of alternative tests in cardiac safety assessments. Moreover, they elaborated on new cardiotoxicological endpoints for which alternative tests can have an impact and provided recommendations on how to cover them.

AB - Cardiotoxicity is among the leading reasons for drug attrition and is therefore a core subject in non-clinical and clinical safety testing of new drugs. European Centre for the Validation of Alternative Methods held in March 2008 a workshop on "Alternative Methods for Drug-induced Cardiotoxicity" in order to promote acceptance of alternative methods reducing, refining or replacing the use of laboratory animals in this field. This review reports the outcome of the workshop. The participants identified the major clinical manifestations, which are sensitive to conventional drugs, to be arrhythmias, contractility toxicity, ischaemia toxicity, secondary cardiotoxicity and valve toxicity. They gave an overview of the current use of alternative tests in cardiac safety assessments. Moreover, they elaborated on new cardiotoxicological endpoints for which alternative tests can have an impact and provided recommendations on how to cover them.

UR - http://www.scopus.com/inward/record.url?scp=77950939863&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950939863&partnerID=8YFLogxK

U2 - 10.1007/s12012-009-9045-3

DO - 10.1007/s12012-009-9045-3

M3 - Article

VL - 9

SP - 107

EP - 125

JO - Cardiovascular Toxicology

JF - Cardiovascular Toxicology

SN - 1530-7905

IS - 3

ER -