Reproducibility of blood pressure response to the cold pressor test

Qi Zhao, Lydia A. Bazzano, Jie Cao, Jianxin Li, Jichun Chen, Jianfeng Huang, Jing Chen, Tanika N. Kelly, Chung Shiuan Chen, Dongsheng Hu, Jixiang Ma, Treva K. Rice, Jiang He, Dongfeng Gu

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

An elevated blood pressure (BP) response to the cold pressor test (CPT) is associated with increased risk of hypertension and cardiovascular disease. However, it is still unclear whether BP response to the CPT is a stable and reproducible trait over time. Using the same study protocol, the authors repeated the CPT 4.5 years after initial administration among 568 Han Chinese in rural northern China (2003-2005 and 2008-2009). BP was measured using a standard mercury sphygmomanometer prior to and 0, 1, 2, and 4 minutes after the participants immersed their hand in ice water (3°C-5°C) for 1 minute. Absolute BP levels and BP responses during the CPT in the initial and repeated administrations were highly correlated. For example, the correlation coefficients were 0.67, 0.73, 0.71, and 0.72 for absolute systolic BP levels at 0, 1, 2, and 4 minutes after ice-water immersion (all P 's < 0.0001). The correlation coefficients for systolic BP response were 0.41 at 0 minutes, 0.37 at 1 minute, 0.42 for maximum response, and 0.39 for the area under the curve during CPT (all P 's < 0.0001). These data indicate that BP response to the CPT is a long-term reproducible and stable characteristic in the general population.

Original languageEnglish (US)
JournalAmerican Journal of Epidemiology
Volume176
Issue numberSUPPL. 7
DOIs
StatePublished - Oct 1 2012

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Blood Pressure
Ice
Sphygmomanometers
Water
Immersion
Mercury
Area Under Curve
China
Cardiovascular Diseases
Hand
Hypertension
Population

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Zhao, Q., Bazzano, L. A., Cao, J., Li, J., Chen, J., Huang, J., ... Gu, D. (2012). Reproducibility of blood pressure response to the cold pressor test. American Journal of Epidemiology, 176(SUPPL. 7). https://doi.org/10.1093/aje/kws294

Reproducibility of blood pressure response to the cold pressor test. / Zhao, Qi; Bazzano, Lydia A.; Cao, Jie; Li, Jianxin; Chen, Jichun; Huang, Jianfeng; Chen, Jing; Kelly, Tanika N.; Chen, Chung Shiuan; Hu, Dongsheng; Ma, Jixiang; Rice, Treva K.; He, Jiang; Gu, Dongfeng.

In: American Journal of Epidemiology, Vol. 176, No. SUPPL. 7, 01.10.2012.

Research output: Contribution to journalArticle

Zhao, Q, Bazzano, LA, Cao, J, Li, J, Chen, J, Huang, J, Chen, J, Kelly, TN, Chen, CS, Hu, D, Ma, J, Rice, TK, He, J & Gu, D 2012, 'Reproducibility of blood pressure response to the cold pressor test', American Journal of Epidemiology, vol. 176, no. SUPPL. 7. https://doi.org/10.1093/aje/kws294
Zhao, Qi ; Bazzano, Lydia A. ; Cao, Jie ; Li, Jianxin ; Chen, Jichun ; Huang, Jianfeng ; Chen, Jing ; Kelly, Tanika N. ; Chen, Chung Shiuan ; Hu, Dongsheng ; Ma, Jixiang ; Rice, Treva K. ; He, Jiang ; Gu, Dongfeng. / Reproducibility of blood pressure response to the cold pressor test. In: American Journal of Epidemiology. 2012 ; Vol. 176, No. SUPPL. 7.
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