Reproductive factors and ovarian cancer risk in African-American women

Patricia G. Moorman, Anthony J. Alberg, Elisa V. Bandera, Jill Barnholtz-Sloan, Melissa Bondy, Michele L. Cote, Ellen Funkhouser, Edward S. Peters, Ann G. Schwartz, Paul Terry, Sydnee Crankshaw, Frances Wang, Joellen M. Schildkraut

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Abstract

Purpose Reproductive characteristics, the most established ovarian cancer risk factors, differ markedly between African-American and white women. Studies in predominantly white populations suggest that associations between reproductive characteristics and ovarian cancer vary by timing of the events and menopause status. This analysis examined associations between number, duration, and timing of reproductive events and epithelial ovarian cancer among African-American women. Methods Data from a multicenter case-control study of ovarian cancer in African-American women (641 cases/752 controls) were used to examine associations with oral contraceptive (OC) use and pregnancy characteristics. Odds ratios (ORs) and 95% confidence intervals (CIs) associated with reproductive characteristics were calculated with logistic regression models. Results OC use (OR = 0.7, 95% CI 0.5–0.9), parity (OR = 0.5, 95% CI 0.3–0.6), and breastfeeding for >12 months (OR = 0.3, 95% CI 0.2–0.5) were inversely associated with ovarian cancer. More recent pregnancies and OC use had stronger associations with ovarian cancer than pregnancies or OC use that occurred earlier in life, especially among premenopausal women. Conclusions This study provides the first thorough documentation that pregnancy, breastfeeding, and OC use are inversely associated with ovarian cancer in African-American women, similar to what has been observed in white women. The associations with timing of the exposures suggest that these factors have both short- and long-term effects.

Original languageEnglish (US)
Pages (from-to)654-662
Number of pages9
JournalAnnals of epidemiology
Volume26
Issue number9
DOIs
StatePublished - Sep 1 2016

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African Americans
Ovarian Neoplasms
Oral Contraceptives
Odds Ratio
Confidence Intervals
Pregnancy
Breast Feeding
Logistic Models
Menopause
Parity
Documentation
Case-Control Studies
Population

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Moorman, P. G., Alberg, A. J., Bandera, E. V., Barnholtz-Sloan, J., Bondy, M., Cote, M. L., ... Schildkraut, J. M. (2016). Reproductive factors and ovarian cancer risk in African-American women. Annals of epidemiology, 26(9), 654-662. https://doi.org/10.1016/j.annepidem.2016.07.004

Reproductive factors and ovarian cancer risk in African-American women. / Moorman, Patricia G.; Alberg, Anthony J.; Bandera, Elisa V.; Barnholtz-Sloan, Jill; Bondy, Melissa; Cote, Michele L.; Funkhouser, Ellen; Peters, Edward S.; Schwartz, Ann G.; Terry, Paul; Crankshaw, Sydnee; Wang, Frances; Schildkraut, Joellen M.

In: Annals of epidemiology, Vol. 26, No. 9, 01.09.2016, p. 654-662.

Research output: Contribution to journalArticle

Moorman, PG, Alberg, AJ, Bandera, EV, Barnholtz-Sloan, J, Bondy, M, Cote, ML, Funkhouser, E, Peters, ES, Schwartz, AG, Terry, P, Crankshaw, S, Wang, F & Schildkraut, JM 2016, 'Reproductive factors and ovarian cancer risk in African-American women', Annals of epidemiology, vol. 26, no. 9, pp. 654-662. https://doi.org/10.1016/j.annepidem.2016.07.004
Moorman PG, Alberg AJ, Bandera EV, Barnholtz-Sloan J, Bondy M, Cote ML et al. Reproductive factors and ovarian cancer risk in African-American women. Annals of epidemiology. 2016 Sep 1;26(9):654-662. https://doi.org/10.1016/j.annepidem.2016.07.004
Moorman, Patricia G. ; Alberg, Anthony J. ; Bandera, Elisa V. ; Barnholtz-Sloan, Jill ; Bondy, Melissa ; Cote, Michele L. ; Funkhouser, Ellen ; Peters, Edward S. ; Schwartz, Ann G. ; Terry, Paul ; Crankshaw, Sydnee ; Wang, Frances ; Schildkraut, Joellen M. / Reproductive factors and ovarian cancer risk in African-American women. In: Annals of epidemiology. 2016 ; Vol. 26, No. 9. pp. 654-662.
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abstract = "Purpose Reproductive characteristics, the most established ovarian cancer risk factors, differ markedly between African-American and white women. Studies in predominantly white populations suggest that associations between reproductive characteristics and ovarian cancer vary by timing of the events and menopause status. This analysis examined associations between number, duration, and timing of reproductive events and epithelial ovarian cancer among African-American women. Methods Data from a multicenter case-control study of ovarian cancer in African-American women (641 cases/752 controls) were used to examine associations with oral contraceptive (OC) use and pregnancy characteristics. Odds ratios (ORs) and 95{\%} confidence intervals (CIs) associated with reproductive characteristics were calculated with logistic regression models. Results OC use (OR = 0.7, 95{\%} CI 0.5–0.9), parity (OR = 0.5, 95{\%} CI 0.3–0.6), and breastfeeding for >12 months (OR = 0.3, 95{\%} CI 0.2–0.5) were inversely associated with ovarian cancer. More recent pregnancies and OC use had stronger associations with ovarian cancer than pregnancies or OC use that occurred earlier in life, especially among premenopausal women. Conclusions This study provides the first thorough documentation that pregnancy, breastfeeding, and OC use are inversely associated with ovarian cancer in African-American women, similar to what has been observed in white women. The associations with timing of the exposures suggest that these factors have both short- and long-term effects.",
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N2 - Purpose Reproductive characteristics, the most established ovarian cancer risk factors, differ markedly between African-American and white women. Studies in predominantly white populations suggest that associations between reproductive characteristics and ovarian cancer vary by timing of the events and menopause status. This analysis examined associations between number, duration, and timing of reproductive events and epithelial ovarian cancer among African-American women. Methods Data from a multicenter case-control study of ovarian cancer in African-American women (641 cases/752 controls) were used to examine associations with oral contraceptive (OC) use and pregnancy characteristics. Odds ratios (ORs) and 95% confidence intervals (CIs) associated with reproductive characteristics were calculated with logistic regression models. Results OC use (OR = 0.7, 95% CI 0.5–0.9), parity (OR = 0.5, 95% CI 0.3–0.6), and breastfeeding for >12 months (OR = 0.3, 95% CI 0.2–0.5) were inversely associated with ovarian cancer. More recent pregnancies and OC use had stronger associations with ovarian cancer than pregnancies or OC use that occurred earlier in life, especially among premenopausal women. Conclusions This study provides the first thorough documentation that pregnancy, breastfeeding, and OC use are inversely associated with ovarian cancer in African-American women, similar to what has been observed in white women. The associations with timing of the exposures suggest that these factors have both short- and long-term effects.

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