Research Directions in Genetic Predispositions to Stevens–Johnson Syndrome / Toxic Epidermal Necrolysis

Teri A. Manolio, Carolyn M. Hutter, Mark Avigan, Ricardo Cibotti, Robert Davis, Joshua C. Denny, Lois La Grenade, Lisa M. Wheatley, Mary N. Carrington, Wasun Chantratita, Wen Hung Chung, Andrea D. Dalton, Shuen Iu Hung, Ming Ta Michael Lee, J. Steven Leeder, Juan J.L. Lertora, Surakameth Mahasirimongkol, Howard L. McLeod, Maja Mockenhaupt, Michael Pacanowski & 10 others Elizabeth J. Phillips, Simone Pinheiro, Munir Pirmohamed, Cynthia Sung, Wimon Suwankesawong, Lauren Trepanier, Santa J. Tumminia, David Veenstra, Rika Yuliwulandari, Neil H. Shear

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is one of the most devastating of adverse drug reactions (ADRs) and was, until recently, essentially unpredictable. With the discovery of several risk alleles for drug-induced SJS/TEN and the demonstration of effectiveness of screening in reducing incidence, the stage is set for implementation of preventive strategies in populations at risk. Yet much remains to be learned about this potentially fatal complication of commonly used drugs.

Original languageEnglish (US)
Pages (from-to)390-394
Number of pages5
JournalClinical Pharmacology and Therapeutics
Volume103
Issue number3
DOIs
StatePublished - Mar 1 2018

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Stevens-Johnson Syndrome
Genetic Predisposition to Disease
Drug-Related Side Effects and Adverse Reactions
Research
Pharmaceutical Preparations
Alleles
Incidence
Direction compound

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Research Directions in Genetic Predispositions to Stevens–Johnson Syndrome / Toxic Epidermal Necrolysis. / Manolio, Teri A.; Hutter, Carolyn M.; Avigan, Mark; Cibotti, Ricardo; Davis, Robert; Denny, Joshua C.; Grenade, Lois La; Wheatley, Lisa M.; Carrington, Mary N.; Chantratita, Wasun; Chung, Wen Hung; Dalton, Andrea D.; Hung, Shuen Iu; Lee, Ming Ta Michael; Leeder, J. Steven; Lertora, Juan J.L.; Mahasirimongkol, Surakameth; McLeod, Howard L.; Mockenhaupt, Maja; Pacanowski, Michael; Phillips, Elizabeth J.; Pinheiro, Simone; Pirmohamed, Munir; Sung, Cynthia; Suwankesawong, Wimon; Trepanier, Lauren; Tumminia, Santa J.; Veenstra, David; Yuliwulandari, Rika; Shear, Neil H.

In: Clinical Pharmacology and Therapeutics, Vol. 103, No. 3, 01.03.2018, p. 390-394.

Research output: Contribution to journalArticle

Manolio, TA, Hutter, CM, Avigan, M, Cibotti, R, Davis, R, Denny, JC, Grenade, LL, Wheatley, LM, Carrington, MN, Chantratita, W, Chung, WH, Dalton, AD, Hung, SI, Lee, MTM, Leeder, JS, Lertora, JJL, Mahasirimongkol, S, McLeod, HL, Mockenhaupt, M, Pacanowski, M, Phillips, EJ, Pinheiro, S, Pirmohamed, M, Sung, C, Suwankesawong, W, Trepanier, L, Tumminia, SJ, Veenstra, D, Yuliwulandari, R & Shear, NH 2018, 'Research Directions in Genetic Predispositions to Stevens–Johnson Syndrome / Toxic Epidermal Necrolysis', Clinical Pharmacology and Therapeutics, vol. 103, no. 3, pp. 390-394. https://doi.org/10.1002/cpt.890
Manolio, Teri A. ; Hutter, Carolyn M. ; Avigan, Mark ; Cibotti, Ricardo ; Davis, Robert ; Denny, Joshua C. ; Grenade, Lois La ; Wheatley, Lisa M. ; Carrington, Mary N. ; Chantratita, Wasun ; Chung, Wen Hung ; Dalton, Andrea D. ; Hung, Shuen Iu ; Lee, Ming Ta Michael ; Leeder, J. Steven ; Lertora, Juan J.L. ; Mahasirimongkol, Surakameth ; McLeod, Howard L. ; Mockenhaupt, Maja ; Pacanowski, Michael ; Phillips, Elizabeth J. ; Pinheiro, Simone ; Pirmohamed, Munir ; Sung, Cynthia ; Suwankesawong, Wimon ; Trepanier, Lauren ; Tumminia, Santa J. ; Veenstra, David ; Yuliwulandari, Rika ; Shear, Neil H. / Research Directions in Genetic Predispositions to Stevens–Johnson Syndrome / Toxic Epidermal Necrolysis. In: Clinical Pharmacology and Therapeutics. 2018 ; Vol. 103, No. 3. pp. 390-394.
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