Residential proximity to major roadways and incident hypertension in post-menopausal women

Samantha L. Kingsley, Melissa N. Eliot, Eric A. Whitsel, Yi Wang, Brent A. Coull, Lifang Hou, Helene G. Margolis, Karen L. Margolis, Lina Mu, Wen Chih C. Wu, Karen Johnson, Matthew A. Allison, Jo Ann E. Manson, Charles B. Eaton, Gregory A. Wellenius

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Living near major roadways has been associated with increased risk of cardiovascular morbidity and mortality, presumably from exposure to elevated levels of traffic-related air and/or noise pollution. This association may potentially be mediated through increased risk of incident hypertension, but results from prior studies are equivocal. Using Cox proportional hazards models we examined residential proximity to major roadways and incident hypertension among 38,360 participants of the Women's Health Initiative (WHI) Clinical Trial cohorts free of hypertension at enrollment and followed for a median of 7.9 years. Adjusting for participant demographics and lifestyle, trial participation, and markers of individual and neighborhood socioeconomic status, the hazard ratios for incident hypertension were 1.13 (95% CI: 1.00, 1.28), 1.03 (0.95, 1.11), 1.05 (0.99, 1.11), and 1.05 (1.00, 1.10) for participants living ≤50, >50-200, >200-400, and >400-1000m vs >1000m from the nearest major roadway, respectively (ptrend=0.013). This association varied substantially by WHI study region with hazard ratios for women living ≤50m from a major roadway of 1.61 (1.18, 2.20) in the West, 1.51 (1.22, 1.87) in the Northeast, 0.89 (0.70, 1.14) in the South, and 0.94 (0.75, 1.19) in the Midwest. In this large, national cohort of post-menopausal women, residential proximity to major roadways was associated with incident hypertension in selected regions of the U.S. If causal, these results suggest residential proximity to major roadways, as a marker for air, noise and other traffic-related pollution, may be a risk factor for hypertension.

Original languageEnglish (US)
Pages (from-to)522-528
Number of pages7
JournalEnvironmental Research
Volume142
DOIs
StatePublished - Oct 1 2015

Fingerprint

hypertension
Hazards
Hypertension
Noise pollution
womens health
hazard
Women's Health
Air
Noise
Pollution
noise pollution
socioeconomic status
Air Pollution
air
morbidity
risk factor
Proportional Hazards Models
lifestyle
Social Class
woman

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Environmental Science(all)

Cite this

Kingsley, S. L., Eliot, M. N., Whitsel, E. A., Wang, Y., Coull, B. A., Hou, L., ... Wellenius, G. A. (2015). Residential proximity to major roadways and incident hypertension in post-menopausal women. Environmental Research, 142, 522-528. https://doi.org/10.1016/j.envres.2015.08.002

Residential proximity to major roadways and incident hypertension in post-menopausal women. / Kingsley, Samantha L.; Eliot, Melissa N.; Whitsel, Eric A.; Wang, Yi; Coull, Brent A.; Hou, Lifang; Margolis, Helene G.; Margolis, Karen L.; Mu, Lina; Wu, Wen Chih C.; Johnson, Karen; Allison, Matthew A.; Manson, Jo Ann E.; Eaton, Charles B.; Wellenius, Gregory A.

In: Environmental Research, Vol. 142, 01.10.2015, p. 522-528.

Research output: Contribution to journalArticle

Kingsley, SL, Eliot, MN, Whitsel, EA, Wang, Y, Coull, BA, Hou, L, Margolis, HG, Margolis, KL, Mu, L, Wu, WCC, Johnson, K, Allison, MA, Manson, JAE, Eaton, CB & Wellenius, GA 2015, 'Residential proximity to major roadways and incident hypertension in post-menopausal women', Environmental Research, vol. 142, pp. 522-528. https://doi.org/10.1016/j.envres.2015.08.002
Kingsley, Samantha L. ; Eliot, Melissa N. ; Whitsel, Eric A. ; Wang, Yi ; Coull, Brent A. ; Hou, Lifang ; Margolis, Helene G. ; Margolis, Karen L. ; Mu, Lina ; Wu, Wen Chih C. ; Johnson, Karen ; Allison, Matthew A. ; Manson, Jo Ann E. ; Eaton, Charles B. ; Wellenius, Gregory A. / Residential proximity to major roadways and incident hypertension in post-menopausal women. In: Environmental Research. 2015 ; Vol. 142. pp. 522-528.
@article{79eab28f7e144d969ab80e769b8ef488,
title = "Residential proximity to major roadways and incident hypertension in post-menopausal women",
abstract = "Living near major roadways has been associated with increased risk of cardiovascular morbidity and mortality, presumably from exposure to elevated levels of traffic-related air and/or noise pollution. This association may potentially be mediated through increased risk of incident hypertension, but results from prior studies are equivocal. Using Cox proportional hazards models we examined residential proximity to major roadways and incident hypertension among 38,360 participants of the Women's Health Initiative (WHI) Clinical Trial cohorts free of hypertension at enrollment and followed for a median of 7.9 years. Adjusting for participant demographics and lifestyle, trial participation, and markers of individual and neighborhood socioeconomic status, the hazard ratios for incident hypertension were 1.13 (95{\%} CI: 1.00, 1.28), 1.03 (0.95, 1.11), 1.05 (0.99, 1.11), and 1.05 (1.00, 1.10) for participants living ≤50, >50-200, >200-400, and >400-1000m vs >1000m from the nearest major roadway, respectively (ptrend=0.013). This association varied substantially by WHI study region with hazard ratios for women living ≤50m from a major roadway of 1.61 (1.18, 2.20) in the West, 1.51 (1.22, 1.87) in the Northeast, 0.89 (0.70, 1.14) in the South, and 0.94 (0.75, 1.19) in the Midwest. In this large, national cohort of post-menopausal women, residential proximity to major roadways was associated with incident hypertension in selected regions of the U.S. If causal, these results suggest residential proximity to major roadways, as a marker for air, noise and other traffic-related pollution, may be a risk factor for hypertension.",
author = "Kingsley, {Samantha L.} and Eliot, {Melissa N.} and Whitsel, {Eric A.} and Yi Wang and Coull, {Brent A.} and Lifang Hou and Margolis, {Helene G.} and Margolis, {Karen L.} and Lina Mu and Wu, {Wen Chih C.} and Karen Johnson and Allison, {Matthew A.} and Manson, {Jo Ann E.} and Eaton, {Charles B.} and Wellenius, {Gregory A.}",
year = "2015",
month = "10",
day = "1",
doi = "10.1016/j.envres.2015.08.002",
language = "English (US)",
volume = "142",
pages = "522--528",
journal = "Environmental Research",
issn = "0013-9351",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Residential proximity to major roadways and incident hypertension in post-menopausal women

AU - Kingsley, Samantha L.

AU - Eliot, Melissa N.

AU - Whitsel, Eric A.

AU - Wang, Yi

AU - Coull, Brent A.

AU - Hou, Lifang

AU - Margolis, Helene G.

AU - Margolis, Karen L.

AU - Mu, Lina

AU - Wu, Wen Chih C.

AU - Johnson, Karen

AU - Allison, Matthew A.

AU - Manson, Jo Ann E.

AU - Eaton, Charles B.

AU - Wellenius, Gregory A.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Living near major roadways has been associated with increased risk of cardiovascular morbidity and mortality, presumably from exposure to elevated levels of traffic-related air and/or noise pollution. This association may potentially be mediated through increased risk of incident hypertension, but results from prior studies are equivocal. Using Cox proportional hazards models we examined residential proximity to major roadways and incident hypertension among 38,360 participants of the Women's Health Initiative (WHI) Clinical Trial cohorts free of hypertension at enrollment and followed for a median of 7.9 years. Adjusting for participant demographics and lifestyle, trial participation, and markers of individual and neighborhood socioeconomic status, the hazard ratios for incident hypertension were 1.13 (95% CI: 1.00, 1.28), 1.03 (0.95, 1.11), 1.05 (0.99, 1.11), and 1.05 (1.00, 1.10) for participants living ≤50, >50-200, >200-400, and >400-1000m vs >1000m from the nearest major roadway, respectively (ptrend=0.013). This association varied substantially by WHI study region with hazard ratios for women living ≤50m from a major roadway of 1.61 (1.18, 2.20) in the West, 1.51 (1.22, 1.87) in the Northeast, 0.89 (0.70, 1.14) in the South, and 0.94 (0.75, 1.19) in the Midwest. In this large, national cohort of post-menopausal women, residential proximity to major roadways was associated with incident hypertension in selected regions of the U.S. If causal, these results suggest residential proximity to major roadways, as a marker for air, noise and other traffic-related pollution, may be a risk factor for hypertension.

AB - Living near major roadways has been associated with increased risk of cardiovascular morbidity and mortality, presumably from exposure to elevated levels of traffic-related air and/or noise pollution. This association may potentially be mediated through increased risk of incident hypertension, but results from prior studies are equivocal. Using Cox proportional hazards models we examined residential proximity to major roadways and incident hypertension among 38,360 participants of the Women's Health Initiative (WHI) Clinical Trial cohorts free of hypertension at enrollment and followed for a median of 7.9 years. Adjusting for participant demographics and lifestyle, trial participation, and markers of individual and neighborhood socioeconomic status, the hazard ratios for incident hypertension were 1.13 (95% CI: 1.00, 1.28), 1.03 (0.95, 1.11), 1.05 (0.99, 1.11), and 1.05 (1.00, 1.10) for participants living ≤50, >50-200, >200-400, and >400-1000m vs >1000m from the nearest major roadway, respectively (ptrend=0.013). This association varied substantially by WHI study region with hazard ratios for women living ≤50m from a major roadway of 1.61 (1.18, 2.20) in the West, 1.51 (1.22, 1.87) in the Northeast, 0.89 (0.70, 1.14) in the South, and 0.94 (0.75, 1.19) in the Midwest. In this large, national cohort of post-menopausal women, residential proximity to major roadways was associated with incident hypertension in selected regions of the U.S. If causal, these results suggest residential proximity to major roadways, as a marker for air, noise and other traffic-related pollution, may be a risk factor for hypertension.

UR - http://www.scopus.com/inward/record.url?scp=84939637645&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939637645&partnerID=8YFLogxK

U2 - 10.1016/j.envres.2015.08.002

DO - 10.1016/j.envres.2015.08.002

M3 - Article

VL - 142

SP - 522

EP - 528

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

ER -