Resistance exercise reduces skeletal muscle cachexia and improves muscle function in rheumatoid arthritis

Salaheddin Sharif, James M. Thomas, David A. Donley, Diana L. Gilleland, Daniel E. Bonner, Jean L. McCrory, W. Guyton Hornsby, Hua Zhao, Mathew W. Lively, Jo Ann A. Hornsby, Stephen Alway

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune, inflammatory disease associated with cachexia (reduced muscle and increased fat). Although strength-training exercise has been used in persons with RA, it is not clear if it is effective for reducing cachexia. A 46-year-old woman was studied to determine: (i) if resistance exercise could reverse cachexia by improving muscle mass, fiber cross-sectional area, and muscle function; and (2) if elevated apoptotic signaling was involved in cachexia with RA and could be reduced by resistance training. A needle biopsy was obtained from the vastus lateralis muscle of the RA subject before and after 16 weeks of resistance training. Knee extensor strength increased by 13.6 and fatigue decreased by 2.8 Muscle mass increased by 2.1. Average muscle fiber cross-sectional area increased by 49.7, and muscle nuclei increased slightly after strength training from 0.08 to 0.12 nuclei/m2. In addition, there was a slight decrease (1.6) in the number of apoptotic muscle nuclei after resistance training. This case study suggests that resistance training may be a good tool for increasing the number of nuclei per fiber area, decreasing apoptotic nuclei, and inducing fiber hypertrophy in persons with RA, thereby slowing or reversing rheumatoid cachexia.

Original languageEnglish (US)
Article number205691
JournalCase Reports in Medicine
Volume2011
DOIs
StatePublished - Jan 1 2011

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Cachexia
Resistance Training
Rheumatoid Arthritis
Skeletal Muscle
Exercise
Muscles
Quadriceps Muscle
Needle Biopsy
Hypertrophy
Autoimmune Diseases
Fatigue
Knee
Fats

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Resistance exercise reduces skeletal muscle cachexia and improves muscle function in rheumatoid arthritis. / Sharif, Salaheddin; Thomas, James M.; Donley, David A.; Gilleland, Diana L.; Bonner, Daniel E.; McCrory, Jean L.; Hornsby, W. Guyton; Zhao, Hua; Lively, Mathew W.; Hornsby, Jo Ann A.; Alway, Stephen.

In: Case Reports in Medicine, Vol. 2011, 205691, 01.01.2011.

Research output: Contribution to journalArticle

Sharif, S, Thomas, JM, Donley, DA, Gilleland, DL, Bonner, DE, McCrory, JL, Hornsby, WG, Zhao, H, Lively, MW, Hornsby, JAA & Alway, S 2011, 'Resistance exercise reduces skeletal muscle cachexia and improves muscle function in rheumatoid arthritis', Case Reports in Medicine, vol. 2011, 205691. https://doi.org/10.1155/2011/205691
Sharif, Salaheddin ; Thomas, James M. ; Donley, David A. ; Gilleland, Diana L. ; Bonner, Daniel E. ; McCrory, Jean L. ; Hornsby, W. Guyton ; Zhao, Hua ; Lively, Mathew W. ; Hornsby, Jo Ann A. ; Alway, Stephen. / Resistance exercise reduces skeletal muscle cachexia and improves muscle function in rheumatoid arthritis. In: Case Reports in Medicine. 2011 ; Vol. 2011.
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