Response and adaptation of skeletal muscle to denervation stress

The role of apoptosis in muscle loss

Parco M. Siu, Stephen Alway

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

Apoptosis is a well-conserved cellular destructive event which has been implicated in a variety of diseases such as cancers and neurodegenerative diseases. The comprehensive investigation of apoptosis has been emerged in the field of skeletal muscle biology. Results have been consistent in demonstrating the activation of apoptotic machinery in different pathologic and physiologic muscle atrophic conditions including muscle disuse, hindlimb unloading, muscle dystrophy, sarcopenia, and neuromuscular diseases. Together with the other identified muscle atrophyrelated signaling mechanisms such as NFκB, FOXOs/MuRF1/MAFbx and ubiquitin-proteasome, apoptosis has been advocated as an important candidate in regulating denervation-induced muscle loss. The purpose of this article is to review the role and signaling mechanisms of apoptosis during denervation in skeletal muscle including myofibers and satellite cells.

Original languageEnglish (US)
Pages (from-to)432-452
Number of pages21
JournalFrontiers in Bioscience
Volume14
Issue number2
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

Fingerprint

Muscle Denervation
Muscle
Skeletal Muscle
Apoptosis
Muscles
Sarcopenia
Hindlimb Suspension
Neuromuscular Diseases
Denervation
Proteasome Endopeptidase Complex
Ubiquitin
Neurodegenerative Diseases
Neurodegenerative diseases
Unloading
Machinery
Chemical activation
Neoplasms
Satellites

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Response and adaptation of skeletal muscle to denervation stress : The role of apoptosis in muscle loss. / Siu, Parco M.; Alway, Stephen.

In: Frontiers in Bioscience, Vol. 14, No. 2, 01.01.2009, p. 432-452.

Research output: Contribution to journalReview article

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