Response of arterial blood pressure, plasma renin activity and plasma aldosterone concentration to long-term administration of captopril in patients with severe, treatment-resistant malignant hypertension

C. S. McCaa, H. G. Langford, William Cushman, R. E. McCaa

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The response of arterial blood pressure, plasma renin activity and plasma aldosterone concentration to inhibition of angiotensin I converting enzyme (kininase II) with captopril has been studied in patients with severe, treatment-resistant, malignant hypertension. Nine patients with a past history of severe hypertension, supine diastolic blood pressure >120 mmHg before conventional antihypertensive therapy and resistant to conventional antihypertensive therapy were studied. Captopril administration resulted in a marked decrease in arterial blood pressure and plasma aldosterone concentration and an increase in plasma renin activity. Although arterial blood pressure remained significantly below the values observed during the control period, pressure did tend to increase again after 3 days. Addition of hydrochlorothiazide kept arterial pressure significantly below pretreatment control values.

Original languageEnglish (US)
Pages (from-to)371-373
Number of pages3
JournalClinical Science
Volume57
Issue numberSUPPL. 5
StatePublished - 1979
Externally publishedYes

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Malignant Hypertension
Captopril
Aldosterone
Renin
Arterial Pressure
Peptidyl-Dipeptidase A
Antihypertensive Agents
Blood Pressure
Hydrochlorothiazide
Therapeutics
Hypertension
Pressure

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "The response of arterial blood pressure, plasma renin activity and plasma aldosterone concentration to inhibition of angiotensin I converting enzyme (kininase II) with captopril has been studied in patients with severe, treatment-resistant, malignant hypertension. Nine patients with a past history of severe hypertension, supine diastolic blood pressure >120 mmHg before conventional antihypertensive therapy and resistant to conventional antihypertensive therapy were studied. Captopril administration resulted in a marked decrease in arterial blood pressure and plasma aldosterone concentration and an increase in plasma renin activity. Although arterial blood pressure remained significantly below the values observed during the control period, pressure did tend to increase again after 3 days. Addition of hydrochlorothiazide kept arterial pressure significantly below pretreatment control values.",
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T1 - Response of arterial blood pressure, plasma renin activity and plasma aldosterone concentration to long-term administration of captopril in patients with severe, treatment-resistant malignant hypertension

AU - McCaa, C. S.

AU - Langford, H. G.

AU - Cushman, William

AU - McCaa, R. E.

PY - 1979

Y1 - 1979

N2 - The response of arterial blood pressure, plasma renin activity and plasma aldosterone concentration to inhibition of angiotensin I converting enzyme (kininase II) with captopril has been studied in patients with severe, treatment-resistant, malignant hypertension. Nine patients with a past history of severe hypertension, supine diastolic blood pressure >120 mmHg before conventional antihypertensive therapy and resistant to conventional antihypertensive therapy were studied. Captopril administration resulted in a marked decrease in arterial blood pressure and plasma aldosterone concentration and an increase in plasma renin activity. Although arterial blood pressure remained significantly below the values observed during the control period, pressure did tend to increase again after 3 days. Addition of hydrochlorothiazide kept arterial pressure significantly below pretreatment control values.

AB - The response of arterial blood pressure, plasma renin activity and plasma aldosterone concentration to inhibition of angiotensin I converting enzyme (kininase II) with captopril has been studied in patients with severe, treatment-resistant, malignant hypertension. Nine patients with a past history of severe hypertension, supine diastolic blood pressure >120 mmHg before conventional antihypertensive therapy and resistant to conventional antihypertensive therapy were studied. Captopril administration resulted in a marked decrease in arterial blood pressure and plasma aldosterone concentration and an increase in plasma renin activity. Although arterial blood pressure remained significantly below the values observed during the control period, pressure did tend to increase again after 3 days. Addition of hydrochlorothiazide kept arterial pressure significantly below pretreatment control values.

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