Response to warfarin and other oral anticoagulants: Effects of disease states

Kutay Demirkan, Mark A. Stephens, Kevin P. Newman, Timothy Self

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Background. Warfarin is associated with numerous drug and food interactions, and much attention has been appropriately focused on this subject. Because several disease states may also affect response to oral anticoagulants, we present a summary of the literature. Methods. We searched MEDLINE for original articles on the effect of disease states on response to warfarin. Results. Liver disease and thyroid dysfunction are well-documented as affecting warfarin response. Further study is needed to establish whether febrile illness, congestive heart failure, and other disease states enhance the effect of warfarin in some patients. Conclusion. Careful monitoring of anticoagulant therapy in patients with diseases that have the potential to affect warfarin response could increase safety and efficacy of this important agent.

Original languageEnglish (US)
Pages (from-to)448-454
Number of pages7
JournalSouthern medical journal
Volume93
Issue number5
DOIs
StatePublished - Jan 1 2000

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Warfarin
Anticoagulants
Food-Drug Interactions
MEDLINE
Liver Diseases
Thyroid Gland
Fever
Heart Failure
Safety

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Response to warfarin and other oral anticoagulants : Effects of disease states. / Demirkan, Kutay; Stephens, Mark A.; Newman, Kevin P.; Self, Timothy.

In: Southern medical journal, Vol. 93, No. 5, 01.01.2000, p. 448-454.

Research output: Contribution to journalArticle

Demirkan, Kutay ; Stephens, Mark A. ; Newman, Kevin P. ; Self, Timothy. / Response to warfarin and other oral anticoagulants : Effects of disease states. In: Southern medical journal. 2000 ; Vol. 93, No. 5. pp. 448-454.
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