Responses of Preterm Pigs to an Oral Fluid Supplement during Parenteral Nutrition

Kirsten Berding, Patty Makarem, Brittany Hance, Anne Marie Dixen Axel, Vikki Nolan, Karyl K. Buddington, Randal Buddington

Research output: Contribution to journalArticle

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Abstract

Background: Nutrients and electrolytes in amniotic fluid swallowed by fetuses are important for growth and development. Yet, preterm infants requiring parenteral nutrition (PN) receive minimal or no oral inputs. With the limited availability of amniotic fluid, we evaluated the responses of preterm pigs receiving PN to an oral fluid supplement (OFS) based on the electrolyte and nutrient composition of amniotic fluid. Materials and Methods: Preterm pigs (92% of term) received a combination of PN (6 mL/kg-h) and 4 mL/kg-h of supplemental fluid as an experimental OFS (n = 9), lactated Ringer's either enterally (n = 10) or intravenously (n = 8). Outcome measures after 96 hours were weight gain, blood chemistry, organ weights, and small intestine mass and brush-border membrane carbohydrases. Results: The OFS did not improve weight gain compared with providing lactated Ringer's orally or intravenously, or increase serum urea nitrogen values, but resulted in higher serum total and low-density lipoprotein cholesterol, as well as improved glucoregulation and heavier intestines, livers, kidneys, and brains and lighter lungs. Conclusions: Providing supplemental fluid and electrolytes during PN either intravenously or orally increases weight gain after preterm birth. An oral fluid supplement based on amniotic fluid may accelerate development and maturation of organs critical for extrauterine life after preterm birth and may enhance neurodevelopment.

Original languageEnglish (US)
Pages (from-to)934-943
Number of pages10
JournalJournal of Parenteral and Enteral Nutrition
Volume40
Issue number7
DOIs
StatePublished - Sep 1 2016

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Parenteral Nutrition
Amniotic Fluid
Swine
Electrolytes
Weight Gain
Premature Birth
Food
Organ Size
Microvilli
Serum
Growth and Development
Premature Infants
LDL Cholesterol
Small Intestine
Intestines
Urea
Fetus
Nitrogen
Outcome Assessment (Health Care)
Kidney

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Responses of Preterm Pigs to an Oral Fluid Supplement during Parenteral Nutrition. / Berding, Kirsten; Makarem, Patty; Hance, Brittany; Axel, Anne Marie Dixen; Nolan, Vikki; Buddington, Karyl K.; Buddington, Randal.

In: Journal of Parenteral and Enteral Nutrition, Vol. 40, No. 7, 01.09.2016, p. 934-943.

Research output: Contribution to journalArticle

Berding, Kirsten ; Makarem, Patty ; Hance, Brittany ; Axel, Anne Marie Dixen ; Nolan, Vikki ; Buddington, Karyl K. ; Buddington, Randal. / Responses of Preterm Pigs to an Oral Fluid Supplement during Parenteral Nutrition. In: Journal of Parenteral and Enteral Nutrition. 2016 ; Vol. 40, No. 7. pp. 934-943.
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