Resting extracellular signal-regulated protein kinase 1/2 expression following a continuum of chronic resistance exercise training paradigms

Andrew J. Galpin, Andrew C. Fry, Justin X. Nicoll, Christopher A. Moore, Brian K. Schilling, Donald Thomason

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Extracellular signal-regulated protein kinase 1/2 (ERK1/2) moderates skeletal muscle growth; however, chronic responses of this protein to unique resistance exercise (RE) paradigms are yet to be explored. The purpose of this investigation was to describe the long-term response of ERK1/2 following circuit weight training (CWT), recreationally weight training (WT), powerlifting (PL) and weightlifting (WL). Independent t-tests were used to determine differences in trained groups compared to sedentary controls. Total ERK1/2 content was lower in PL and WL compared to their controls (p ≤ 0.05). Specific trained groups displayed large (WL: pERK/total-ERK; d = 1.25) and moderate (CWT: total ERK1/2; d = 0.54) effect sizes for altered kinase expression compared to controls. The results indicate ERK1/2 expression is down-regulated after chronic RE in well-trained weightlifters and powerlifters. Lower expression of this protein may be a method in which anabolism is tightly regulated after many years of high-intensity RE.

Original languageEnglish (US)
Pages (from-to)298-303
Number of pages6
JournalResearch in Sports Medicine
Volume24
Issue number3
DOIs
StatePublished - Jul 2 2016

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Mitogen-Activated Protein Kinase 3
Resistance Training
Protein Kinases
Exercise
Weights and Measures
Skeletal Muscle
Proteins
Phosphotransferases
Growth

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Resting extracellular signal-regulated protein kinase 1/2 expression following a continuum of chronic resistance exercise training paradigms. / Galpin, Andrew J.; Fry, Andrew C.; Nicoll, Justin X.; Moore, Christopher A.; Schilling, Brian K.; Thomason, Donald.

In: Research in Sports Medicine, Vol. 24, No. 3, 02.07.2016, p. 298-303.

Research output: Contribution to journalArticle

Galpin, Andrew J. ; Fry, Andrew C. ; Nicoll, Justin X. ; Moore, Christopher A. ; Schilling, Brian K. ; Thomason, Donald. / Resting extracellular signal-regulated protein kinase 1/2 expression following a continuum of chronic resistance exercise training paradigms. In: Research in Sports Medicine. 2016 ; Vol. 24, No. 3. pp. 298-303.
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