Rete testis-associated nodular steroid cell nests: Description of putative pluripotential testicular hilus steroid cells

Gladell P. Paner, Glen Kristiansen, Jesse K. McKenney, Mahul Amin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A putative hilus interstitial cell has been proposed as the cell of origin for testicular tumors of adrenogenital syndrome, but its normal histology is not documented. We present hitherto undescribed nodular steroid cell nests associated with the rete testis that are distinctive in their morphology and immunohistochemical profile from Leydig cells and do not have the morphology of typical extra-adrenal cortical rests. These nodules measured 1, 1, 1.8, 2, and 2.5 mm in size with a distinct sinusoidal vasculature. Individual cells were rounded to polygonal with evenly distributed moderate-to-abundant eosinophilic cytoplasm. The nuclei were homogenous and round, with fine chromatin and occassionally with prominent nucleoli. The differential diagnosis included adrenocortical rests, testicular adnexal Leydig cells, carcinoid tumorlets, paraganglionic rests, and adenomatoid mesothelial proliferation. Immunohistochemistry showed positivity for melan A (5/5), inhibin (3/5), and calretinin (2/4), although the immunoreactivity was distinctively different from the concurrent intratesticular Leydig cells and testicular adnexal Leydig cells in all cases. The unique morphology, immunophenotype, and distinctive location of these cells in the testicular mediastinum raises the possibility that these cells represent testicular hilus steroid cells, the putative histogenetic cell implicated for testicular tumors of adrenogenital syndrome. We propose to name these proliferations rete testis-associated nodular steroid cell nests.

Original languageEnglish (US)
Pages (from-to)505-511
Number of pages7
JournalAmerican Journal of Surgical Pathology
Volume35
Issue number4
DOIs
StatePublished - Apr 1 2011
Externally publishedYes

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Rete Testis
Steroids
Leydig Cells
Adrenogenital Syndrome
Testicular Neoplasms
MART-1 Antigen
Calbindin 2
Inhibins
Carcinoid Tumor
Mediastinum
Chromatin
Names
Histology
Cytoplasm
Differential Diagnosis
Immunohistochemistry

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Rete testis-associated nodular steroid cell nests : Description of putative pluripotential testicular hilus steroid cells. / Paner, Gladell P.; Kristiansen, Glen; McKenney, Jesse K.; Amin, Mahul.

In: American Journal of Surgical Pathology, Vol. 35, No. 4, 01.04.2011, p. 505-511.

Research output: Contribution to journalArticle

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