Retinoblastoma in Jordan

An epidemiological study (2006-2010)

Ibrahim Alnawaiseh, Imad Jaradat, Yacoub A. Yousef, Mustafa Mehyar, Iyad Sultan, Samer Khurma, Khalil Al-Rawashded, Matthew Wilson, Ibrahim Qaddoumi, Ahmed Salem

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

BACKGROUND AND OBJECTIVE: The epidemiological characteristics of retinoblastoma have been extensively studied in developed countries, however epidemiological data is scarce in the Middle East. We present a dettailed epidemiological analysis of retinoblastoma in Jordan in an attempt to aid national and regional strategies for improved cancer surveillance and control. DESIGN AND SETTING: Retrospective review of retinoblastoma cases presenting to the sole and exclusive ocular oncology referral center in Jordan. PATIENTS AND METHODS: Forty children (59 eyes) presenting with clinically and/or histologically confirmed retinoblastomas were treated at King Hussein Cancer Center (Amman, Jordan) between January 2006 and December 2010. This case series included 28 boys and 12 girls. Data relating to age at diagnosis, laterality, gender, treatment modality and survival were recorded. RESULTS: The mean age-adjusted incidence of retinoblastoma in Jordan was 9.32 cases per million children per year for children aged 0-5 years. The male: female ratio was 2.3:1. Bilateral cases were encountered in 19 pattients (47.5%) while 21 patients (52.5%) harbored unilateral retinoblastoma. At the time of follow-up, 38 patients (95%) were alive. Overall, 40 eyes (67.8%) were successfully preserved without the need for enucleation. CONCLUSIONS: The national epidemiological data gathered in this study indicates that the incidence of retinobblastoma in Jordan is similar to that reported in various countries of the world. Jordanian boys, however, are at significantly higher risk for developing retinoblastoma than age-matched girls. Furthermore, Jordanian patients are more likely to harbor bilateral retinoblastoma.

Original languageEnglish (US)
Pages (from-to)126-131
Number of pages6
JournalHematology/ Oncology and Stem Cell Therapy
Volume4
Issue number3
DOIs
StatePublished - Jan 1 2011

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Jordan
Retinoblastoma
Epidemiologic Studies
Middle East
Developed Countries
Neoplasms
Cohort Studies
Referral and Consultation
Survival
Incidence

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology

Cite this

Alnawaiseh, I., Jaradat, I., Yousef, Y. A., Mehyar, M., Sultan, I., Khurma, S., ... Salem, A. (2011). Retinoblastoma in Jordan: An epidemiological study (2006-2010). Hematology/ Oncology and Stem Cell Therapy, 4(3), 126-131. https://doi.org/10.5144/1658-3876.2011.126

Retinoblastoma in Jordan : An epidemiological study (2006-2010). / Alnawaiseh, Ibrahim; Jaradat, Imad; Yousef, Yacoub A.; Mehyar, Mustafa; Sultan, Iyad; Khurma, Samer; Al-Rawashded, Khalil; Wilson, Matthew; Qaddoumi, Ibrahim; Salem, Ahmed.

In: Hematology/ Oncology and Stem Cell Therapy, Vol. 4, No. 3, 01.01.2011, p. 126-131.

Research output: Contribution to journalReview article

Alnawaiseh, I, Jaradat, I, Yousef, YA, Mehyar, M, Sultan, I, Khurma, S, Al-Rawashded, K, Wilson, M, Qaddoumi, I & Salem, A 2011, 'Retinoblastoma in Jordan: An epidemiological study (2006-2010)', Hematology/ Oncology and Stem Cell Therapy, vol. 4, no. 3, pp. 126-131. https://doi.org/10.5144/1658-3876.2011.126
Alnawaiseh I, Jaradat I, Yousef YA, Mehyar M, Sultan I, Khurma S et al. Retinoblastoma in Jordan: An epidemiological study (2006-2010). Hematology/ Oncology and Stem Cell Therapy. 2011 Jan 1;4(3):126-131. https://doi.org/10.5144/1658-3876.2011.126
Alnawaiseh, Ibrahim ; Jaradat, Imad ; Yousef, Yacoub A. ; Mehyar, Mustafa ; Sultan, Iyad ; Khurma, Samer ; Al-Rawashded, Khalil ; Wilson, Matthew ; Qaddoumi, Ibrahim ; Salem, Ahmed. / Retinoblastoma in Jordan : An epidemiological study (2006-2010). In: Hematology/ Oncology and Stem Cell Therapy. 2011 ; Vol. 4, No. 3. pp. 126-131.
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abstract = "BACKGROUND AND OBJECTIVE: The epidemiological characteristics of retinoblastoma have been extensively studied in developed countries, however epidemiological data is scarce in the Middle East. We present a dettailed epidemiological analysis of retinoblastoma in Jordan in an attempt to aid national and regional strategies for improved cancer surveillance and control. DESIGN AND SETTING: Retrospective review of retinoblastoma cases presenting to the sole and exclusive ocular oncology referral center in Jordan. PATIENTS AND METHODS: Forty children (59 eyes) presenting with clinically and/or histologically confirmed retinoblastomas were treated at King Hussein Cancer Center (Amman, Jordan) between January 2006 and December 2010. This case series included 28 boys and 12 girls. Data relating to age at diagnosis, laterality, gender, treatment modality and survival were recorded. RESULTS: The mean age-adjusted incidence of retinoblastoma in Jordan was 9.32 cases per million children per year for children aged 0-5 years. The male: female ratio was 2.3:1. Bilateral cases were encountered in 19 pattients (47.5{\%}) while 21 patients (52.5{\%}) harbored unilateral retinoblastoma. At the time of follow-up, 38 patients (95{\%}) were alive. Overall, 40 eyes (67.8{\%}) were successfully preserved without the need for enucleation. CONCLUSIONS: The national epidemiological data gathered in this study indicates that the incidence of retinobblastoma in Jordan is similar to that reported in various countries of the world. Jordanian boys, however, are at significantly higher risk for developing retinoblastoma than age-matched girls. Furthermore, Jordanian patients are more likely to harbor bilateral retinoblastoma.",
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AU - Yousef, Yacoub A.

AU - Mehyar, Mustafa

AU - Sultan, Iyad

AU - Khurma, Samer

AU - Al-Rawashded, Khalil

AU - Wilson, Matthew

AU - Qaddoumi, Ibrahim

AU - Salem, Ahmed

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N2 - BACKGROUND AND OBJECTIVE: The epidemiological characteristics of retinoblastoma have been extensively studied in developed countries, however epidemiological data is scarce in the Middle East. We present a dettailed epidemiological analysis of retinoblastoma in Jordan in an attempt to aid national and regional strategies for improved cancer surveillance and control. DESIGN AND SETTING: Retrospective review of retinoblastoma cases presenting to the sole and exclusive ocular oncology referral center in Jordan. PATIENTS AND METHODS: Forty children (59 eyes) presenting with clinically and/or histologically confirmed retinoblastomas were treated at King Hussein Cancer Center (Amman, Jordan) between January 2006 and December 2010. This case series included 28 boys and 12 girls. Data relating to age at diagnosis, laterality, gender, treatment modality and survival were recorded. RESULTS: The mean age-adjusted incidence of retinoblastoma in Jordan was 9.32 cases per million children per year for children aged 0-5 years. The male: female ratio was 2.3:1. Bilateral cases were encountered in 19 pattients (47.5%) while 21 patients (52.5%) harbored unilateral retinoblastoma. At the time of follow-up, 38 patients (95%) were alive. Overall, 40 eyes (67.8%) were successfully preserved without the need for enucleation. CONCLUSIONS: The national epidemiological data gathered in this study indicates that the incidence of retinobblastoma in Jordan is similar to that reported in various countries of the world. Jordanian boys, however, are at significantly higher risk for developing retinoblastoma than age-matched girls. Furthermore, Jordanian patients are more likely to harbor bilateral retinoblastoma.

AB - BACKGROUND AND OBJECTIVE: The epidemiological characteristics of retinoblastoma have been extensively studied in developed countries, however epidemiological data is scarce in the Middle East. We present a dettailed epidemiological analysis of retinoblastoma in Jordan in an attempt to aid national and regional strategies for improved cancer surveillance and control. DESIGN AND SETTING: Retrospective review of retinoblastoma cases presenting to the sole and exclusive ocular oncology referral center in Jordan. PATIENTS AND METHODS: Forty children (59 eyes) presenting with clinically and/or histologically confirmed retinoblastomas were treated at King Hussein Cancer Center (Amman, Jordan) between January 2006 and December 2010. This case series included 28 boys and 12 girls. Data relating to age at diagnosis, laterality, gender, treatment modality and survival were recorded. RESULTS: The mean age-adjusted incidence of retinoblastoma in Jordan was 9.32 cases per million children per year for children aged 0-5 years. The male: female ratio was 2.3:1. Bilateral cases were encountered in 19 pattients (47.5%) while 21 patients (52.5%) harbored unilateral retinoblastoma. At the time of follow-up, 38 patients (95%) were alive. Overall, 40 eyes (67.8%) were successfully preserved without the need for enucleation. CONCLUSIONS: The national epidemiological data gathered in this study indicates that the incidence of retinobblastoma in Jordan is similar to that reported in various countries of the world. Jordanian boys, however, are at significantly higher risk for developing retinoblastoma than age-matched girls. Furthermore, Jordanian patients are more likely to harbor bilateral retinoblastoma.

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