Review

interactions between H2-antagonists and non-steroidal anti-inflammatory drugs.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are being prescribed increasingly with an H2-antagonist. This article reviews those published studies which have examined the potential for pharmacokinetic and, where appropriate, pharmacodynamic interactions between these classes of drugs. Studies involving the administration of a single dose of a NSAID to young healthy volunteers are of limited relevance in establishing the likely effect of an H2-antagonist on the blood concentrations of an NSAID in patients. Appropriate studies are those which will examine the effects of H2-antagonists on the steady-state pharmacokinetics of NSAIDs in patients with inflammatory joint diseases. More of such studies are required, particularly involving elderly patients.

Original languageEnglish (US)
Pages (from-to)93-100
Number of pages8
JournalAlimentary pharmacology & therapeutics
Volume2
Issue number2
StatePublished - Jan 1 1988
Externally publishedYes

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Anti-Inflammatory Agents
Pharmaceutical Preparations
Pharmacokinetics
Joint Diseases
Healthy Volunteers

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

Cite this

Review : interactions between H2-antagonists and non-steroidal anti-inflammatory drugs. / Howden, Colin.

In: Alimentary pharmacology & therapeutics, Vol. 2, No. 2, 01.01.1988, p. 93-100.

Research output: Contribution to journalReview article

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