Review of renal anastomosing hemangioma with focus on clinical and pathological aspects

Naoto Kuroda, Chisato Ohe, Sirohi Deepika, Kenji Yorita, Shuji Mikami, Mitsuko Furuya, Yoji Nagashima, Ondrej Hes, Abbas Agaimy, Michal Michal, Mahul Amin

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Renal anastomosing hemangiomas (RAH) has been recently proposed as a new entity. In this article, we summarize the clinicopathologic features of this tumor. RAH usually develops on a background of end-stage renal disease. Macroscopically, tumors are well-defined and their cut surface shows mahogany brown spongy tissue with epicenter in the renal medulla. Tumors are usually small, but larger lesions are reported. On microscopic examination, the tumor consists of sinusoid-like vascular channels lined by cuboidal endothelial cells with occasional hobnail-like appearance of endothelial cells closely mimicking splenic sinusoids. Eosinophilic hyaline globules may be present in the cytoplasm of neoplastic endothelial cells. Extramedullary hematopoiesis containing erythroid precursor and megakaryocytes may be present in the vascular lumens. Immunohistochemically, endothelial cells are positive for CD31 and CD34, but negative for D2-40, GLUT-1 and HHV8. The surrounding stroma around endothelial cells demonstrates positivity for a smooth muscle action. To date, there are no studies on molecular genetic aspects of RAH. This tumor is indolent based on site and size of the lesion, partial or nephrectomy is sufficient as a therapeutic modality.

Original languageEnglish (US)
Pages (from-to)97-101
Number of pages5
JournalPolish Journal of Pathology
Volume67
Issue number2
DOIs
StatePublished - Jan 1 2016

Fingerprint

Hemangioma
Endothelial Cells
Kidney
Neoplasms
Blood Vessels
Extramedullary Hematopoiesis
Hyalin
Megakaryocytes
Nephrectomy
Chronic Kidney Failure
Smooth Muscle
Molecular Biology
Cytoplasm
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Review of renal anastomosing hemangioma with focus on clinical and pathological aspects. / Kuroda, Naoto; Ohe, Chisato; Deepika, Sirohi; Yorita, Kenji; Mikami, Shuji; Furuya, Mitsuko; Nagashima, Yoji; Hes, Ondrej; Agaimy, Abbas; Michal, Michal; Amin, Mahul.

In: Polish Journal of Pathology, Vol. 67, No. 2, 01.01.2016, p. 97-101.

Research output: Contribution to journalReview article

Kuroda, N, Ohe, C, Deepika, S, Yorita, K, Mikami, S, Furuya, M, Nagashima, Y, Hes, O, Agaimy, A, Michal, M & Amin, M 2016, 'Review of renal anastomosing hemangioma with focus on clinical and pathological aspects', Polish Journal of Pathology, vol. 67, no. 2, pp. 97-101. https://doi.org/10.5114/pjp.2016.61443
Kuroda, Naoto ; Ohe, Chisato ; Deepika, Sirohi ; Yorita, Kenji ; Mikami, Shuji ; Furuya, Mitsuko ; Nagashima, Yoji ; Hes, Ondrej ; Agaimy, Abbas ; Michal, Michal ; Amin, Mahul. / Review of renal anastomosing hemangioma with focus on clinical and pathological aspects. In: Polish Journal of Pathology. 2016 ; Vol. 67, No. 2. pp. 97-101.
@article{08abbc7e2d9b48e186c18b10d84f6cc0,
title = "Review of renal anastomosing hemangioma with focus on clinical and pathological aspects",
abstract = "Renal anastomosing hemangiomas (RAH) has been recently proposed as a new entity. In this article, we summarize the clinicopathologic features of this tumor. RAH usually develops on a background of end-stage renal disease. Macroscopically, tumors are well-defined and their cut surface shows mahogany brown spongy tissue with epicenter in the renal medulla. Tumors are usually small, but larger lesions are reported. On microscopic examination, the tumor consists of sinusoid-like vascular channels lined by cuboidal endothelial cells with occasional hobnail-like appearance of endothelial cells closely mimicking splenic sinusoids. Eosinophilic hyaline globules may be present in the cytoplasm of neoplastic endothelial cells. Extramedullary hematopoiesis containing erythroid precursor and megakaryocytes may be present in the vascular lumens. Immunohistochemically, endothelial cells are positive for CD31 and CD34, but negative for D2-40, GLUT-1 and HHV8. The surrounding stroma around endothelial cells demonstrates positivity for a smooth muscle action. To date, there are no studies on molecular genetic aspects of RAH. This tumor is indolent based on site and size of the lesion, partial or nephrectomy is sufficient as a therapeutic modality.",
author = "Naoto Kuroda and Chisato Ohe and Sirohi Deepika and Kenji Yorita and Shuji Mikami and Mitsuko Furuya and Yoji Nagashima and Ondrej Hes and Abbas Agaimy and Michal Michal and Mahul Amin",
year = "2016",
month = "1",
day = "1",
doi = "10.5114/pjp.2016.61443",
language = "English (US)",
volume = "67",
pages = "97--101",
journal = "Polish Journal of Pathology",
issn = "1233-9687",
publisher = "Versalius University Medical Publisher",
number = "2",

}

TY - JOUR

T1 - Review of renal anastomosing hemangioma with focus on clinical and pathological aspects

AU - Kuroda, Naoto

AU - Ohe, Chisato

AU - Deepika, Sirohi

AU - Yorita, Kenji

AU - Mikami, Shuji

AU - Furuya, Mitsuko

AU - Nagashima, Yoji

AU - Hes, Ondrej

AU - Agaimy, Abbas

AU - Michal, Michal

AU - Amin, Mahul

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Renal anastomosing hemangiomas (RAH) has been recently proposed as a new entity. In this article, we summarize the clinicopathologic features of this tumor. RAH usually develops on a background of end-stage renal disease. Macroscopically, tumors are well-defined and their cut surface shows mahogany brown spongy tissue with epicenter in the renal medulla. Tumors are usually small, but larger lesions are reported. On microscopic examination, the tumor consists of sinusoid-like vascular channels lined by cuboidal endothelial cells with occasional hobnail-like appearance of endothelial cells closely mimicking splenic sinusoids. Eosinophilic hyaline globules may be present in the cytoplasm of neoplastic endothelial cells. Extramedullary hematopoiesis containing erythroid precursor and megakaryocytes may be present in the vascular lumens. Immunohistochemically, endothelial cells are positive for CD31 and CD34, but negative for D2-40, GLUT-1 and HHV8. The surrounding stroma around endothelial cells demonstrates positivity for a smooth muscle action. To date, there are no studies on molecular genetic aspects of RAH. This tumor is indolent based on site and size of the lesion, partial or nephrectomy is sufficient as a therapeutic modality.

AB - Renal anastomosing hemangiomas (RAH) has been recently proposed as a new entity. In this article, we summarize the clinicopathologic features of this tumor. RAH usually develops on a background of end-stage renal disease. Macroscopically, tumors are well-defined and their cut surface shows mahogany brown spongy tissue with epicenter in the renal medulla. Tumors are usually small, but larger lesions are reported. On microscopic examination, the tumor consists of sinusoid-like vascular channels lined by cuboidal endothelial cells with occasional hobnail-like appearance of endothelial cells closely mimicking splenic sinusoids. Eosinophilic hyaline globules may be present in the cytoplasm of neoplastic endothelial cells. Extramedullary hematopoiesis containing erythroid precursor and megakaryocytes may be present in the vascular lumens. Immunohistochemically, endothelial cells are positive for CD31 and CD34, but negative for D2-40, GLUT-1 and HHV8. The surrounding stroma around endothelial cells demonstrates positivity for a smooth muscle action. To date, there are no studies on molecular genetic aspects of RAH. This tumor is indolent based on site and size of the lesion, partial or nephrectomy is sufficient as a therapeutic modality.

UR - http://www.scopus.com/inward/record.url?scp=84982871943&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84982871943&partnerID=8YFLogxK

U2 - 10.5114/pjp.2016.61443

DO - 10.5114/pjp.2016.61443

M3 - Review article

VL - 67

SP - 97

EP - 101

JO - Polish Journal of Pathology

JF - Polish Journal of Pathology

SN - 1233-9687

IS - 2

ER -