Review of salt consumption and stomach cancer risk

Epidemiological and biological evidence

Xiao Qin Wang, Paul Terry, Hong Yan

Research output: Contribution to journalReview article

109 Citations (Scopus)

Abstract

Stomach cancer is still the fourth most common cancer; thus, it remains an important public health burden worldwide, especially in developing countries. The remarkable geographic variations in the rates of stomach cancer indicate that dietary factors, including a range of food groups to which salt and/or nitrates have been added, may affect stomach cancer risk. In this paper, we review the results from ecologic, case-control and cohort studies on the relationship between salt or salted foods and stomach cancer risk. The majority of ecological studies indicated that the average salt intake in each population was closely correlated with gastric cancer mortality. Most case-control studies showed similar results, indicating a moderate to high increase in risk for the highest level of salt or salted food consumption. The overall results from cohort studies are not totally consistent, but are suggestive of a moderate direct association. Since salt intake has been correlated with Helicobacter pylori (H pylori) infection, it is possible that these two factors may synergize to promote the development of stomach cancer. Additionally, salt may also cause stomach cancer through directly damaging gastric mucus, improving temporary epithelial proliferation and the incidence of endogenous mutations, and inducing hypergastrinemia that leads to eventual parietal cell loss and progression to gastric cancer. Based on the considerable evidence from ecological, case-control and cohort studies worldwide and the mechanistic plausibility, limitation on salt and salted food consumption is a practical strategy for preventing gastric cancer.

Original languageEnglish (US)
Pages (from-to)2204-2213
Number of pages10
JournalWorld Journal of Gastroenterology
Volume15
Issue number18
DOIs
StatePublished - May 14 2009
Externally publishedYes

Fingerprint

Stomach Neoplasms
Salts
Case-Control Studies
Food
Cohort Studies
Helicobacter Infections
Mucus
Helicobacter pylori
Nitrates
Developing Countries
Stomach
Public Health
Mutation
Mortality
Incidence
Population
Neoplasms

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Review of salt consumption and stomach cancer risk : Epidemiological and biological evidence. / Wang, Xiao Qin; Terry, Paul; Yan, Hong.

In: World Journal of Gastroenterology, Vol. 15, No. 18, 14.05.2009, p. 2204-2213.

Research output: Contribution to journalReview article

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