Risk factors for colorectal adenomas among immediate family members of patients with colorectal cancer in Taiwan

A case-control study

Virender K. Sharma, Rajeev Vasudeva, Colin Howden

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

OBJECTIVES: The incidence of colorectal cancer or adenoma among first-degree relatives of patients with colorectal cancer is significantly high. However, a well defined screening and surveillance consensus has not been developed for these families in Taiwan. We conducted this study to evaluate the colorectal adenoma prevalence pattern in screened immediate family members in Taiwan, and to derive implications for future screening programs. METHODS: A total of 234 immediate family members (aged 51.6 ± 21.5 yr) of 186 patients with colorectal cancer were offered a colonoscopy. Each relative examined was then paired with two control subjects for age, sex, and symptoms. The prevalence of colorectal adenomas was then compared using multiple logistic regression analysis. RESULTS: The estimated risk of developing adenomas among immediate family members of patients with colorectal cancer was significantly increased (OR = 2.33; 95% CI, 1.43-3.78; p < 0.001). This trend was more striking for men (OR = 2.46; 95% CI, 1.40-4.31; p = 0.001). Immediate family members were at an increased risk for high-risk adenomas (≥ 1.0 cm, with a villous component, and/or with severe dysplasia) (OR = 4.5; 95% CI, 1.91-10.60; p = 0.002), and developed adenomas at an earlier age than did controls. Individuals with index cancer relatives diagnosed at <50 yr of age or male relatives posed a higher risk of developing colorectal adenomas. CONCLUSIONS: The prevalence of colorectal adenoma in persons with a colorectal cancer family history in Taiwan is similar to that reported in Western countries. This high-risk population should be offered a screening colonoscopy beginning at 40 yr of age. (C) 2000 by Am. Coll. of Gastroenterology.

Original languageEnglish (US)
Pages (from-to)3624-3628
Number of pages5
JournalAmerican Journal of Gastroenterology
Volume95
Issue number12
DOIs
StatePublished - 2000
Externally publishedYes

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Taiwan
Adenoma
Case-Control Studies
Colorectal Neoplasms
Colonoscopy
Gastroenterology
Consensus
Logistic Models
Regression Analysis
Incidence
Population

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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Risk factors for colorectal adenomas among immediate family members of patients with colorectal cancer in Taiwan : A case-control study. / Sharma, Virender K.; Vasudeva, Rajeev; Howden, Colin.

In: American Journal of Gastroenterology, Vol. 95, No. 12, 2000, p. 3624-3628.

Research output: Contribution to journalArticle

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abstract = "OBJECTIVES: The incidence of colorectal cancer or adenoma among first-degree relatives of patients with colorectal cancer is significantly high. However, a well defined screening and surveillance consensus has not been developed for these families in Taiwan. We conducted this study to evaluate the colorectal adenoma prevalence pattern in screened immediate family members in Taiwan, and to derive implications for future screening programs. METHODS: A total of 234 immediate family members (aged 51.6 ± 21.5 yr) of 186 patients with colorectal cancer were offered a colonoscopy. Each relative examined was then paired with two control subjects for age, sex, and symptoms. The prevalence of colorectal adenomas was then compared using multiple logistic regression analysis. RESULTS: The estimated risk of developing adenomas among immediate family members of patients with colorectal cancer was significantly increased (OR = 2.33; 95{\%} CI, 1.43-3.78; p < 0.001). This trend was more striking for men (OR = 2.46; 95{\%} CI, 1.40-4.31; p = 0.001). Immediate family members were at an increased risk for high-risk adenomas (≥ 1.0 cm, with a villous component, and/or with severe dysplasia) (OR = 4.5; 95{\%} CI, 1.91-10.60; p = 0.002), and developed adenomas at an earlier age than did controls. Individuals with index cancer relatives diagnosed at <50 yr of age or male relatives posed a higher risk of developing colorectal adenomas. CONCLUSIONS: The prevalence of colorectal adenoma in persons with a colorectal cancer family history in Taiwan is similar to that reported in Western countries. This high-risk population should be offered a screening colonoscopy beginning at 40 yr of age. (C) 2000 by Am. Coll. of Gastroenterology.",
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