Risk factors for discharge on a new antipsychotic medication after admission to an intensive care unit

Anthony Rowe, Leslie Hamilton, Rachel A. Curtis, Camellia R. Davis, Leslie N. Smith, Grayson K. Peek, Victoria W. Reynolds

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose: Increased awareness of delirium in the intensive care unit (ICU) has led to higher use of antipsychotic medications for treatment of delirium. These medications are often not discontinued at ICU or hospital discharge, which may increase the risk of inappropriate polypharmacy. Our study sought to identify risk factors for being discharged on a new antipsychotic medication after admission to a trauma-surgical ICU or neurocritical care unit. Methods: This was a retrospective cohort study at an academic medical center and included patients who were admitted to the trauma-surgical ICU or neurocritical care unit and received an antipsychotic medication. Those younger than 18 years, died before hospital discharge, or did not have complete documentation were excluded. Results: A total of 341 records were included in the final analysis. Of those, 82 (24%) were discharged on a new antipsychotic and 67% of those patients had no documented indication. Acute Physiology and Chronic Health Evaluation II (odds ratio, 1.030 [95% confidence interval, 1.030-1.110]) and days treated with benzodiazepines (odds ratio, 1.101 [95% confidence interval, 1.060-1.143]) were independently associated with being discharged on a new antipsychotic medication. Conclusions: Those patients with higher Acute Physiology and Chronic Health Evaluation II scores and more benzodiazepine days are at increased odds of being discharged on a new antipsychotic.

Original languageEnglish (US)
Article number51921
Pages (from-to)1283-1286
Number of pages4
JournalJournal of Critical Care
Volume30
Issue number6
DOIs
StatePublished - Dec 1 2015

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Antipsychotic Agents
Intensive Care Units
APACHE
Delirium
Critical Care
Benzodiazepines
Odds Ratio
Confidence Intervals
Polypharmacy
Wounds and Injuries
Documentation
Cohort Studies
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine

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Risk factors for discharge on a new antipsychotic medication after admission to an intensive care unit. / Rowe, Anthony; Hamilton, Leslie; Curtis, Rachel A.; Davis, Camellia R.; Smith, Leslie N.; Peek, Grayson K.; Reynolds, Victoria W.

In: Journal of Critical Care, Vol. 30, No. 6, 51921, 01.12.2015, p. 1283-1286.

Research output: Contribution to journalArticle

Rowe, Anthony ; Hamilton, Leslie ; Curtis, Rachel A. ; Davis, Camellia R. ; Smith, Leslie N. ; Peek, Grayson K. ; Reynolds, Victoria W. / Risk factors for discharge on a new antipsychotic medication after admission to an intensive care unit. In: Journal of Critical Care. 2015 ; Vol. 30, No. 6. pp. 1283-1286.
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